Reference Report

Reference
Citation	Reynolds-Kenneally, J., Mlodzik, M. (2005). Notch signaling controls proliferation through cell-autonomous and non-autonomous mechanisms in the Drosophila eye. Dev. Biol. 285(1): 38--48. (Export to RIS)
FlyBase ID	FBrf0187397
Publication Type	Research paper
PubMed ID	16039641
PubMed Abstract	During Drosophila eye development, localized Notch signaling at the dorsal ventral (DV)-midline promotes growth of the entire eye field. This long-range action of Notch signaling may be mediated through the diffusible ligand of the Jak/STAT pathway, Unpaired (Upd), which was recently identified as a downstream target of Notch. However, Notch activity has not been shown to be cell-autonomously required for Upd expression and therefore yet another diffusible signal may be required for Notch activation of Upd. Our results clarify the Notch requirement, demonstrating that Notch activity at the DV-midline leads to cell-autonomous expression of Upd as monitored in loss and gain-of-function Notch clones. In addition, mutations in the Jak/STAT pathway interact genetically with the Notch pathway by suppressing Notch mediated overgrowth. N(act) clones show non-autonomous effects on the cell cycle anterior to the furrow, indicating function of the Jak/STAT pathway. However, cell-autonomous effects of Notch within and posterior to the furrow are independent of Upd. Here, Notch autonomously maintains cells in a proliferative state and blocks photoreceptor differentiation.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Biol.
Title	Developmental Biology
Publication Year	1959-
ISBN/ISSN	0012-1606
Data from Reference
Aberrations (1)
	Df(1)N-54l9
Alleles (14)
	Avic\GFP^Scer\UAS.cUa Dl^Scer\UAS.cHa dome^G0218 dome^G0282 eyg⁶⁸⁵ hop²⁵ N^ICN.Scer\UAS os⁵⁴ Rnor\CD2^HLHmβ.PdC Scer\GAL4^Act5C.PP Scer\GAL4^ey.PH Scer\GAL4^upd-E132 Ser^Scer\UAS.cSa Stat92E^j6C8
Constructs (7)
	P{GAL4-Act5C(-FRT).P} P{GAL4-ey.H} P{HLHmβ-CD2.dC} P{UAS-Dl.H} P{UAS-GFP.U} P{UAS-N.ICN} P{UAS-Ser.mg5603}
Genes (18)
	ato Avic\GFP CycB Dl Dll dome elav ey eya eyg His3 hop N os Rnor\CD2 Scer\GAL4 Ser Stat92E
Insertions (4)
	P{GawB}E132 P{lacW}dome^G0218 P{lacW}dome^G0282 P{lacW}Stat92E^j6C8