Reference Report

Reference
Citation	Wei, S.Y., Escudero, L.M., Yu, F., Chang, L.H., Chen, L.Y., Ho, Y.H., Lin, C.M., Chou, C.S., Chia, W., Modolell, J., Hsu, J.C. (2005). Echinoid is a component of adherens junctions that cooperates with DE-Cadherin to mediate cell adhesion. Dev. Cell 8(4): 493--504. (Export to RIS)
FlyBase ID	FBrf0187414
Publication Type	Research paper
PubMed ID	15809032
PubMed Abstract	Echinoid is an immunoglobulin domain-containing transmembrane protein that modulates cell-cell signaling by Notch and the EGF receptors. We show that, in the Drosophila wing disc epithelium, Echinoid is a component of adherens junctions that cooperates with DE-Cadherin in cell adhesion. Echinoid and beta-catenin (a DE-Cadherin interacting protein) each possess a C-terminal PDZ domain binding motif that binds to Bazooka/PAR-3; these motifs redundantly position Bazooka to adherens junctions. Echinoid also links to actin filaments by binding to Canoe/AF-6/afadin. Moreover, interfaces between Echinoid- and Echinoid+ cells, like those between DE-Cadherin- and DE-Cadherin+ cells, are deficient in adherens junctions and form actin cables. These characteristics probably facilitate the strong sorting behavior of cells that lack either of these cell-adhesion molecules. Finally, cells lacking either Echinoid or DE-Cadherin accumulate a high density of the reciprocal protein, further suggesting that Echinoid and DE-Cadherin play similar and complementary roles in cell adhesion.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Cell
Title	Developmental Cell
Publication Year	2001-
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Data from Reference
Alleles (6)
	baz⁴ ed^1X5 ed^Scer\UAS.cBa Scer\GAL4^ap-md544 shg¹ smo³
Constructs (1)
	P{UAS-ed.B}
Genes (24)
	Act5C Act42A arm baz ci cno crb ct dlg1 ed Egfr en Inx2 Inx3 N par-6 Scer\GAL4 scrib sens shg smo sqh wek zip
Insertions (1)
	P{GawB}ap^md544