Reference Report

Reference
Citation	Audibert, A., Simon, F., Gho, M. (2005). Cell cycle diversity involves differential regulation of Cyclin E activity in the Drosophila bristle cell lineage. Development 132(10): 2287--2297. (Export to RIS)
FlyBase ID	FBrf0187449
Publication Type	Research paper
PubMed ID	15829522
PubMed Abstract	In the Drosophila bristle lineage, five differentiated cells arise from a precursor cell after a rapid sequence of asymmetric cell divisions (one every 2 hours). We show that, in mitotic cells, this rapid cadence of cell divisions is associated with cell cycles essentially devoid of the G1-phase. This feature is due to the expression of Cyclin E that precedes each cell division, and the differential expression of the S-transition negative regulator, Dacapo. Thus, apart from endocycles (G/S), which occurred in two out of five terminal cells, two other cell cycles coexist in this lineage: (1) an atypical cell cycle (S/G2/M), in which the S-phase is initiated during the preceding telophase; and (2) a canonical cell cycle (G1/S/G2/M) with a brief G1 phase. These two types of cell cycle result from either the absence or very transient expression of Dap, respectively. Finally, we show that the fate determinant factor, Tramtrack, downregulates Cyclin E expression and is probably involved in the exit of the cells from the cell cycle.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Alleles (10)
	CycE^Scer\UAS.cLa dap⁴ dap^Scer\UAS.cLa Ecol\lacZ^neur-A101 Hsap\HIST2H2BE^{Scer\UAS.T:Avic\GFP-YFP} Scer\GAL4^hs.PB Scer\GAL4^neur-P72 T:Avic\GFP^YFP ttk^1e11 ttk^69.Scer\UAS
Constructs (5)
	P{GAL4-Hsp70.PB} P{UAS-CycE.L} P{UAS-dap.L} P{UAS-H2B-T:Avic\GFP-YFP} P{UAS-ttk.69.B}
Genes (14)
	CycE dap Ecol\lacZ elav Hsap\HIST2H2BE Lam pros Scer\GAL4 sens Su(H) ttk αTub84B αTub84D αTub85E
Insertions (2)
	P{GAL4}neur^P72 P{lArB}neur^A101