Reference Report

Reference
Citation	Franch-Marro, X., Marchand, O., Piddini, E., Ricardo, S., Alexandre, C., Vincent, J.P. (2005). Glypicans shunt the Wingless signal between local signalling and further transport. Development 132(4): 659--666. (Export to RIS)
FlyBase ID	FBrf0187459
Publication Type	Research paper
PubMed ID	15647318
PubMed Abstract	The two glypicans Dally and Dally-like have been implicated in modulating the activity of Wingless, a member of the Wnt family of secreted glycoprotein. So far, the lack of null mutants has prevented a rigorous assessment of their roles. We have created a small deletion in the two loci. Our analysis of single and double mutant embryos suggests that both glypicans participate in normal Wingless function, although embryos lacking maternal and zygotic activity of both genes are still capable of transducing the signal from overexpressed Wingless. Genetic analysis of dally-like in wing imaginal discs leads us to a model whereby, at the surface of any given cell of the epithelium, Dally-like captures Wingless but instead of presenting it to signalling receptors expressed in this cell, it passes it on to neighbouring cells, either for paracrine signalling or for further transport. In the absence of dally-like, short-range signalling is increased at the expense of long-range signalling (reported by the expression of the target gene distalless) while the reverse is caused by Dally-like overexpression. Thus, Dally-like act as a gatekeeper, ensuring the sharing of Wingless among cells along the dorsoventral axis. Our analysis suggests that the other glypican, Dally, could act as a classical co-receptor.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Alleles (16)
	Avic\GFP^{S65T.Ubi-p63E} dally⁰⁶⁴⁶⁴ dally^MH32 dally^{Scer\UAS.T:Ivir\HA1} dally^{Scer\UAS.T:Zzzz\FLAG} dlp^MH20 dlp^{Scer\UAS.T:Ivir\HA1} hh^AC Scer\GAL4^dpp.blk1 Scer\GAL4^en-e16E Scer\GAL4^MtnA.PC Scer\GAL4^{Scer\FRT.Rnor\CD2.αTub84B} Scer\GAL4^sim.PS Scer\GAL4^αTub84B.PP wg^l-17 wg^{Scer\UAS.T:Avic\GFP}
Constructs (9)
	P{GAL4-dpp.blk1} P{GAL4-sim.S} P{GAL4-αTub84B(FRT.CD2).P} P{GAL4-αTub84B(-FRT).P} P{UAS-dally.FLAG} P{UAS-dally.HA} P{UAS-dlp.HA} P{UAS-GFP-wg} P{Ubi-GFP.S65T}
Genes (12)
	Avic\GFP dally Dll dlp hh rho Scer\GAL4 sens T:Avic\GFP T:Ivir\HA1 T:Zzzz\FLAG wg
Insertions (4)
	P{?'PZ}hh^AC P{en2.4-GAL4}e16E P{GSV6}9068 P{GSV6}11297
Natural transposons (1)
	P-element