Reference Report

Reference
Citation	Merabet, S., Hombria, J.C., Hu, N., Pradel, J., Graba, Y. (2005). Hox-controlled reorganisation of intrasegmental patterning cues underlies Drosophila posterior spiracle organogenesis. Development 132(13): 3093--3102. (Export to RIS)
FlyBase ID	FBrf0187474
Publication Type	Research paper
PubMed ID	15930099
PubMed Abstract	Hox proteins provide axial positional information and control segment morphology in development and evolution. Yet how they specify morphological traits that confer segment identity and how axial positional information interferes with intrasegmental patterning cues during organogenesis remain poorly understood. We have investigated the control of Drosophila posterior spiracle morphogenesis, a segment-specific structure that forms under Abdominal-B (AbdB) Hox control in the eighth abdominal segment (A8). We show that the Hedgehog (Hh), Wingless (Wg) and Epidermal Growth Factor Receptor (Egfr) pathways provide specific inputs for posterior spiracle morphogenesis and act in a genetic network made of multiple and rapidly evolving Hox/signalling interplays. A major function of AbdB during posterior spiracle organogenesis is to reset A8 intrasegmental patterning cues, first by reshaping wg and rhomboid expression patterns, then by reallocating the Hh signal and later by initiating de novo expression of the posterior compartment gene engrailed in anterior compartment cells. These changes in expression patterns confer axial specificity to otherwise reiteratively used segmental patterning cues, linking intrasegmental polarity and acquisition of segment identity.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Alleles (22)
	Abd-B^M5 Avic\GFP^{E.Scer\UAS.cMa} ci^{N:Zn.Scer\UAS} Ecol\lacZ^ems.1.2 Ecol\lacZ^Scer\UAS.cUa Egfr^{DN.Scer\UAS.cBa} Egfr^f2 Egfr^tsla en^E en^Scer\UAS.cGa hh²¹ hh^ts2 pan^ΔN.Scer\UAS Ras85D^V12.Scer\UAS Scer\GAL4^69B Scer\GAL4^ems.HRE Scer\GAL4^en-e16E Scer\GAL4^salm-459.2 spi^s.Scer\UAS wg^l-12 wg^l-17 wg^Scer\UAS.cLb
Constructs (11)
	P{ems-GAL4.HRE} P{ems-lacZ.1.2} P{UAS>wg} P{UAS-ciN/Zn} P{UAS-EGFP.M} P{UAS-Egfr.DN.B} P{UAS-en.G} P{UAS-lacZ.U} P{UAS-pan.dTCFΔN} P{UAS-Ras85D.V12} P{UAS-spi.s}
Genes (16)
	Abd-B Avic\GFP ci ct Ecol\lacZ Egfr ems en hh pan Ras85D rho salm Scer\GAL4 spi wg
Insertions (3)
	P{en2.4-GAL4}e16E P{GawB}69B P{GawB}459.2