Reference Report

Reference
Citation	Collier, S., Lee, H., Burgess, R., Adler, P. (2005). The WD40 repeat protein fritz links cytoskeletal planar polarity to frizzled subcellular localization in the Drosophila epidermis. Genetics 169(4): 2035--2045. (Export to RIS)
FlyBase ID	FBrf0187636
Publication Type	Research paper
PubMed ID	15654087
PubMed Abstract	Much of our understanding of the genetic mechanisms that control planar cell polarity (PCP) in epithelia has derived from studies of the formation of polarized cell hairs during Drosophila wing development. The correct localization of an F-actin prehair to the distal vertex of the pupal wing cell has been shown to be dependent upon the polarized subcellular localization of Frizzled and other core PCP proteins. However, the core PCP proteins do not organize actin cytoskeletal polarity directly but require PCP effector proteins such as Fuzzy and Inturned to mediate this process. Here we describe the characterization of a new PCP effector gene, fritz, that encodes a novel but evolutionarily conserved coiled-coil WD40 protein. We show that the fritz gene product functions cell-autonomously downstream of the core PCP proteins to regulate both the location and the number of wing cell prehair initiation sites.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (9)
	Df(2L)dp-79b Df(2L)F.1 Df(2L)frtz11 Df(2L)frtz14 Df(2L)frtz19 Df(2L)frtz24 Df(2L)frtz25 Df(2L)frtz⁷ Df(2L)S2
Alleles (22)
	CG18317^frtz-7 frtz¹ frtz² frtz³ frtz⁷ frtz²⁶ frtz²⁷ frtz²⁸ frtz²⁹ frtz³⁰ frtz³³ frtz^unspecified fy⁵ fz²¹ fz^{arm.T:Avic\GFP-EGFP} in^II53 pk^{sple.Scer\UAS} Scer\GAL4^Act.PU Scer\GAL4^bi-md653 stan^Scer\UAS.cUa T:Avic\GFP^EGFP trc^unspecified
Constructs (3)
	P{arm-fz.GFP} P{UAS-fmi.U} P{UAS-sple⁺}
Genes (17)
	CG17646 CG17652 CG17660 CG18317 CG31937 cpb dsh Eno frtz fy fz in mRpL48 pk Scer\GAL4 stan trc
Insertions (1)
	P{GawB}bi^md653
Natural transposons (1)
	mdg3