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Reference
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| Citation |
Glasscock, E., Singhania, A., Tanouye, M.A. (2005). The mei-P26 Gene Encodes a RING Finger B-box Coiled-Coil-NHL Protein That Regulates Seizure Susceptibility in Drosophilia. Genetics 170(4): 1677--1689. |
| FlyBase ID |
FBrf0187640 |
| Type of publication |
Research paper |
| Offprint Available |
No |
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External Crossreferences
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| PubMed ID |
15937125 |
| PubMed Abstract |
Seizure-suppressor mutations provide unique insight into the genes and mechanisms involved in regulating nervous system excitability.
Drosophila bang-sensitive (BS) mutants present a useful tool for identifying seizure suppressors since they are a well-characterized
epilepsy model. Here we describe the isolation and characterization of a new Drosophila seizure-suppressor mutant that results
from disruption of the meiotic gene mei-P26, which belongs to the RBCC-NHL family of proteins. The mei-P26 mutation reduces
seizures in easily shocked (eas) and slamdance (sda) epileptic flies following mechanical stimulation and electroconvulsive
shock. In addition, mutant mei-P26 flies exhibit seizure thresholds at least threefold greater than those of wild type. The
mei-P26 phenotypes appear to result from missense mutation of a critical residue in the NHL protein-protein interaction domain
of the protein. These results reveal a surprising role for mei-P26 outside of the germline as a regulator of seizure susceptibility,
possibly by affecting synaptic development as a ubiquitin ligase.
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| Biosis |
2005.10337923 |
| Zoological record |
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Associated Information
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| Text of personal communication |
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Related Publications
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Also Published As
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Other Reference Information
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| Secondary IDs |
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| Language of publication |
English |
| Additional language(s) of abstract |
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| ISBN |
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Published In
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| Abbreviation |
Genetics |
| Title |
Genetics |
| Authors |
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| Volume range |
1- |
| Year range |
1916- |
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| Publisher |
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| Place of publication |
Austin, TX, etc |
| Language of publication |
English |
| ISBN/ISSN |
0016-6731 |
| CODEN |
GENTAE |
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Data from Reference
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| Aberrations (6)
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| Alleles (7)
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| Constructs (1)
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| Genes (19)
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| Insertions (2)
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