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Citation
Kristensen, T.N., Sorensen, P., Kruhoffer, M., Pedersen, K.S., Loeschcke, V. (2005). Genome-wide analysis on inbreeding effects on gene expression in Drosophila melanogaster.  Genetics 171(1): 157--167.
FlyBase ID
FBrf0187643
Publication Type
Research paper
Abstract

The deleterious consequences of inbreeding, especially in the form of inbreeding depression, are well known. However, little is known about how inbreeding affects genome-wide gene expression. Here, we show that inbreeding changes transcription levels for a number of genes. Gene expression profiles of Drosophila melanogaster lines inbred to F approximately = 0.67 at different rates changed relative to those of noninbred lines, but the rate of inbreeding did not significantly affect gene expression patterns. Genes being differentially expressed with inbreeding are disproportionately involved in metabolism and stress responses, suggesting that inbreeding acts like an environmental stress factor.

PubMed ID
PubMed Central ID
PMC1456508 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genetics
    Title
    Genetics
    Publication Year
    1916-
    ISBN/ISSN
    0016-6731
    Data From Reference