Reference Report

Reference
Citation	Melnikova, L., Biessmann, H., Georgiev, P. (2005). The Ku protein complex is involved in length regulation of Drosophila telomeres. Genetics 170(1): 221--235. (Export to RIS)
FlyBase ID	FBrf0187650
Publication Type	Research paper
PubMed ID	15781709
PubMed Abstract	Chromosome ends in Drosophila melanogaster can be elongated either by terminal attachment of the telomere-specific retrotransposons HeT-A and TART or by terminal gene conversion. Here we show that a decrease in Ku70 or Ku80 gene dosage causes a sharp increase in the frequency of HeT-A and TART attachments to a broken chromosome end and in terminal DNA elongation by gene conversion. Loss of Ku80 has more pronounced effects than loss of Ku70. However, lower Ku70 concentration reduces the stability of terminally deficient chromosomes. Our results suggest a role of the end-binding Ku complex in the accessibility and length regulation of Drosophila telomeres.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (14)
	Df(1)y^TD2h2-900 Df(1)y^TD2h2-1100 Df(1)y^TD-700 Df(1)y^TDrh-2200 Df(1)y^TDrh-3400 Df(1)y^TDrh-4400 Df(1)y^TDrh-5000 Df(1)y^TDrh-5100 Df(1)y^TDrh-5400 Df(1)y^TDrh-8000 Df(2L)r10 Df(2L)TE35BC-24 Df(3R)M-Kx1 Df(3R)thoR1
Alleles (10)
	y^TD2h2-900 y^TD2h2-1100 y^TD2h2 y^TDrh-2200 y^TDrh-3400 y^TDrh-4400 y^TDrh-5000 y^TDrh-5100 y^TDrh-5400 y^TDrh-8000
Genes (3)
	Irbp Ku80 y
Natural transposons (2)
	HeT-A TART-element