Reference Report

Reference
Citation	Zhu, M.Y., Wilson, R., Leptin, M. (2005). A screen for genes that influence fibroblast growth factor signal transduction in Drosophila. Genetics 170(2): 767--777. (Export to RIS)
FlyBase ID	FBrf0187664
Publication Type	Research paper
External Crossreferences
PubMed ID	15834142
PubMed Abstract	The misexpression of an activated form of the FGF receptor (FGFR) Breathless in conjunction with downstream-of-FGF-receptor (Dof), an essential signaling molecule of the FGF pathway, in the Drosophila eye imaginal discs impairs eye development and results in a rough eye phenotype. We used this phenotype in a gain-of-function screen to search for modifiers of FGF signaling. We identified 50 EP stocks with insertions defining at least 35 genes that affect the rough eye phenotype. Among these genes, 4 appear to be specific for FGFR signaling, but most of the genes also influence other signaling pathways, as assessed by their effects on rough eyes induced by other activated receptor tyrosine kinases (RTKs). Analysis of loss-of-function alleles of a number of these genes in embryos indicates that in many cases the products are provided maternally and are involved in germ cell development. At least two of the genes, sar1 and robo2, show a genetic interaction with a hypomorphic dof allele, suggesting that they participate in FGF-mediated morphogenetic events during embryogenesis.
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FB2012_01
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Supplementary material	Supplemental Data. [FBrf0207611]
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Editors
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (2)
	Df(1)N-81k1 Df(2R)rl10a
Alleles (101)
	14-3-3ζ⁰⁷¹⁰³ ago^EP1135 amn^EP367 amn^EP1323 Amun^EP1503 Atg1^EP3348 ball⁴³ ball⁵³ ball^EP863 ball^unspecified BEST:GH17330^EP1408 bol^EP3659 btl::Egfr^{Scer\UAS.T:λ\cI-DD} btl^{Scer\UAS.T:λ\cI-DD} Cdc42^L89.Scer\UAS CG1090^EP3028 CG3542^3.3 CG3542^9.3 CG3542^9.4 CG3542^15.5 CG3542^18.2 CG3542^35.1 CG3542^EP719 CG3542^unspecified CG4266^EP2258 CG7231^EP2510 CG10082^EP436 CG10082^EP2310 CG10082^EP2319 CG10082^EP2440 CG10321^EP1222 CG10433^EP2034 CG10433^EP2516 CHES-1-like^EP1342 CHES-1-like^EP1453 csw^Esev1A-eOP CycA^C8LR1 CycB^{CBTPM.Scer\UAS.P\T.T:Avic\GFP} dco^EP3280 Dlc90F^EP3634 dock⁰⁴⁷²³ dock¹³⁴²¹ dos^P115 drk^e0A drk^k02401 dsh¹ Dsor1^LH110 Dsp1^EP355 Eip78C^EP3468 EP595b^EP595b EP712^EP712 EP1200^EP1200 EP1207^EP1207 EP1216b^EP1216b EP1340^EP1340 EP2204^EP2204 EP2444^EP2444 EP2494^EP2494 fz¹ Gap1^1-16 HmgD^EP467 Hmt4-20^EP1216a htl^{Scer\UAS.T:λ\cI-DD} ksr^s721 lea^EP2582 lea^robo2-8 lilli^EP1211 MESR4^EP988 NFAT^EP1335 NFAT^EP1353 NFAT^EP1390 NFAT^EP1508 phl¹ phl⁷ Pvr^{Scer\UAS.T:λ\cI-DD} Rac1^N17.Scer\UAS Ras85D^e2F Rho1^72R RhoGEF2⁰⁴²⁹¹ rl¹⁰ rl^10a sar1²⁸ sar1⁷¹ sar1^EP3575 sar1^unspecified Scer\GAL4^GMR.PF skd^EP3443 skpA^EP1216a Smg5^EP2171 Sos^e4G stan^E59 stumps^ems7 stumps^{Scer\UAS.T:Zzzz\FLAG} T:λ\cI^DD Tao-1^EP1455 Tim10^EP541 Tim10^EP2421 tlk^EP1413 tou^EP622 Tsp42Ef^EP2571 w^+mC
Constructs (6)
	P{GAL4-ninaE.GMR} P{UAS-btl.λ} P{UAS-Egfr.λtop} P{UAS-htl.λ\cI.M} P{UAS-stumps.Flag} P{UAS-λ-Pvr}
Genes (82)
	14-3-3ζ ago amn Amun Ance Atg1 ball BEST:GH17330 bol btl btl::Egfr Cdc42 CG1090 CG3542 CG4266 CG6745 CG6765 CG7231 CG9650 CG10082 CG10321 CG10433 CHES-1-like CR32730 csw CycA dco Dlc90F dock dos drk dsh Dsor1 Dsp1 Eip78C EP595b EP712 EP1200 EP1207 EP1216b EP1340 EP2204 EP2444 EP2494 fz Gap1 HmgD Hmt4-20 htl Imp ksr l(3)05822 lea lilli MESR4 NFAT phl Ppcdc PTP-ER Pvr Rac1 Ras85D Rho1 RhoGEF2 rl Sap130 sar1 Scer\GAL4 skd skpA Smg5 Sos stan stumps T:Zzzz\FLAG T:λ\cI Tao-1 Tim10 tlk tou Tsp42Ef w
Insertions (52)
	P{EP}ago^EP1135 P{EP}amn^EP367 P{EP}amn^EP1323 P{EP}Amun^EP1503 P{EP}Atg1^EP3348 P{EP}ball^EP863 P{EP}BEST:GH17330^EP1408 P{EP}bol^EP3659 P{EP}CG1090^EP3028 P{EP}CG3542^EP719 P{EP}CG4266^EP2258 P{EP}CG6745^EP595b P{EP}CG7231^EP2510 P{EP}CG9650^EP1340 P{EP}CG10082^EP436 P{EP}CG10082^EP2310 P{EP}CG10082^EP2319 P{EP}CG10082^EP2440 P{EP}CG10321^EP1222 P{EP}CG10433^EP2034 P{EP}CG10433^EP2516 P{EP}CHES-1-like^EP1342 P{EP}CHES-1-like^EP1453 P{EP}dco^EP3280 P{EP}Dlc90F^EP3634 P{EP}Dsp1^EP355 P{EP}Eip78C^EP3468 P{EP}EP712^EP712 P{EP}EP1200^EP1200 P{EP}EP1207^EP1207 P{EP}EP1216b^EP1216b P{EP}EP2204^EP2204 P{EP}EP2444^EP2444 P{EP}EP2494^EP2494 P{EP}HmgD^EP467 P{EP}Hmt4-20^EP1216a P{EP}lea^EP2582 P{EP}lilli^EP1211 P{EP}MESR4^EP988 P{EP}NFAT^EP1335 P{EP}NFAT^EP1353 P{EP}NFAT^EP1390 P{EP}NFAT^EP1508 P{EP}sar1^EP3575 P{EP}skd^EP3443 P{EP}Smg5^EP2171 P{EP}Tao-1^EP1455 P{EP}Tim10^EP541 P{EP}Tim10^EP2421 P{EP}tlk^EP1413 P{EP}tou^EP622 P{EP}Tsp42Ef^EP2571
Transcripts (3)
	CG4266-XR Tao-1-XR Tim10-XR