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Reference
Citation
Birch-Machin, I., Gao, S., Huen, D., McGirr, R., White, R.A., Russell, S. (2005). Genomic analysis of heat-shock factor targets in Drosophila.  Genome Biol. 6(7): R63.
FlyBase ID
FBrf0187687
Publication Type
Research paper
Abstract

We have used a chromatin immunoprecipitation-microarray (ChIP-array) approach to investigate the in vivo targets of heat-shock factor (Hsf) in Drosophila embryos. We show that this method identifies Hsf target sites with high fidelity and resolution. Using cDNA arrays in a genomic search for Hsf targets, we identified 141 genes with highly significant ChIP enrichment. This study firmly establishes the potential of ChIP-array for whole-genome transcription factor target mapping in vivo using intact whole organisms.

PubMed ID
PubMed Central ID
PMC1175994 (PMC) (EuropePMC)
Associated Information
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Secondary IDs
  • FBrf0190801
Language of Publication
English
Additional Languages of Abstract
Parent Publication
Publication Type
Journal
Abbreviation
Genome Biol.
Title
Genome Biology
Publication Year
2000-
ISBN/ISSN
1474-7596 1474-760X
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