Reference Report

Reference
Citation	Martini, S.R., Davis, R.L. (2005). The dachshund gene is required for the proper guidance and branching of mushroom body axons in Drosophila melanogaster. J. Neurobiol. 64(2): 133--144. (Export to RIS)
FlyBase ID	FBrf0187878
Publication Type	Research paper
PubMed ID	15818552
PubMed Abstract	The dachshund gene encodes a transcription factor required for the proper development of Drosophila eyes, legs, and mushroom bodies. The mushroom bodies of dachshund mutants exhibit a marked reduction in the size of the vertical lobes and disorganization of the horizontal lobes. In mosaic animals, mutant axons fail to contribute significantly to the mushroom body alpha lobe. Here we show that this defect is due to the misrouting of alphabeta axons to the region normally occupied by alpha'beta' axons. This defect is pronounced for clones generated in larval stages but not clones generated after pupariation, indicating that dachshund function is particularly important around the time of puparium formation. In addition, mushroom body axons exhibit excessive branching in dachshund mutant clones. Thus, dachshund is required in mushroom body neurons for proper axon guidance and branching.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	J. Neurobiol.
Title	Journal of Neurobiology
Publication Year	1969-
ISBN/ISSN	0022-3034
Data from Reference
Aberrations (1)
	Df(2L)dac-4
Alleles (8)
	dac³ Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Scer\GAL4^17d Scer\GAL4^c320 Scer\GAL4^c739 Scer\GAL4^ey-OK107 Scer\GAL4^Mz984 Scer\GAL4^Tab2-201Y
Constructs (1)
	P{UAS-mCD8::GFP.L}
Genes (5)
	dac Fas2 Mmus\Cd8a Scer\GAL4 trio
Insertions (6)
	P{GAL4}17d P{GAL4}c320 P{GawB}ey^OK107 P{GawB}Hr39^c739 P{GawB}Mz984 P{GawB}Tab2^201Y