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Citation
Torroja, C., Gorfinkiel, N., Guerrero, I. (2005). Mechanisms of Hedgehog gradient formation and interpretation.  J. Neurobiol. 64(4): 334--356.
FlyBase ID
FBrf0187882
Publication Type
Review
Abstract
Morphogens are molecules that spread from localized sites of production, specifying distinct cell outcomes at different concentrations. Members of the Hedgehog (Hh) family of signaling molecules act as morphogens in different developmental systems. If we are to understand how Hh elicits multiple responses in a temporally and spatially specific manner, the molecular mechanism of Hh gradient formation needs to be established. Moreover, understanding the mechanisms of Hh signaling is a central issue in biology, not only because of the role of Hh in morphogenesis, but also because of its involvement in a wide range of human diseases. Here, we review the mechanisms affecting the dynamics of Hh gradient formation, mostly in the context of Drosophila wing development, although parallel findings in vertebrate systems are also discussed.
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    J. Neurobiol.
    Title
    Journal of Neurobiology
    Publication Year
    1969-
    ISBN/ISSN
    0022-3034
    Data From Reference