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Möller, A., Avila, F.W., Erickson, J.W., Jäckle, H. (2005). Drosophila BAP60 is an essential component of the Brahma complex, required for gene activation and repression.  J. Mol. Biol. 352(2): 329--337.
FlyBase ID
FBrf0187959
Publication Type
Research paper
Abstract

The SWI/SNF-like chromatin remodeling complex of Drosophila, the Brahma complex, contains four subunits (Brahma, BAP155/Moira, SNR1 and BAP60) conserved from yeast to humans. A reconstituted human complex lacking the BAP60 homolog shows full remodeling activity, suggesting that BAP60 is not essential for the core function. We generated Drosophila mutants and found that BAP60 carries a vital function and participates in complex-mediated transcriptional activation and repression. BAP60 binds DNA and shows genetic and physical interactions with the sex-determining transcription factors encoded by sisterless A and scute. The results support the conclusion that BAP60 participates in site-specific recruitment of the Brahma complex in Drosophila.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    J. Mol. Biol.
    Title
    Journal of Molecular Biology
    Publication Year
    1959-
    ISBN/ISSN
    0022-2836
    Data From Reference
    Aberrations (6)
    Alleles (12)
    Genes (11)
    Physical Interactions (4)
    Cell Lines (1)
    Natural transposons (1)
    Insertions (1)
    Transgenic Constructs (1)