Open Close
Reference
Citation
Straight, A.F., Field, C.M., Mitchison, T.J. (2005). Anillin binds nonmuscle myosin II and regulates the contractile ring.  Mol. Biol. Cell 16(1): 193--201.
FlyBase ID
FBrf0188073
Publication Type
Research paper
Abstract

We demonstrate that the contractile ring protein anillin interacts directly with nonmuscle myosin II and that this interaction is regulated by myosin light chain phosphorylation. We show that despite their interaction, anillin and myosin II are independently targeted to the contractile ring. Depletion of anillin in Drosophila or human cultured cells results in cytokinesis failure. Human cells depleted for anillin fail to properly regulate contraction by myosin II late in cytokinesis and fail in abscission. We propose a role for anillin in spatially regulating the contractile activity of myosin II during cytokinesis.

PubMed ID
PubMed Central ID
PMC539163 (PMC) (EuropePMC)
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Mol. Biol. Cell
    Title
    Molecular Biology of the Cell
    Publication Year
    1992-
    ISBN/ISSN
    1059-1524
    Data From Reference
    Genes (4)
    Cell Lines (1)