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Citation
Quesneville, H., Nouaud, D., Anxolabehere, D. (2005). Recurrent recruitment of the THAP DNA-binding domain and molecular domestication of the p-transposable element.  Mol. Biol. Evol. 22(3): 741--746.
FlyBase ID
FBrf0188091
Publication Type
Research paper
Abstract
The recently described THAP domain motif characterizes a DNA-binding domain (DBD) that is widely conserved in human and in animals. It presents a similarity with the DBD of the P element transposase of D. melanogaster. We show here that the P Drosophila neogenes derived from P-transposable elements conserve the THAP domain. Moreover, secondary rearrangements by exon shuffling indicate the recurrent recruitment of this domain by the host genome. As P sequences and THAP genes are found together in many animal genomes, we discuss the possibility that the THAP proteins have acquired their domain as a result of recurrent molecular domestication of P-transposable elements.
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Mol. Biol. Evol.
    Title
    Molecular Biology and Evolution
    Publication Year
    1983-
    ISBN/ISSN
    0737-4038 1537-1719
    Data From Reference
    Genes (3)
    Natural transposons (1)