Reference Report

Reference
Citation	do Amaral, V.S., da Silva, R.M., Reguly, M.L., Rodrigues de Andrade, H.H. (2005). Drosophila wing-spot test for genotoxic assessment of pollutants in water samples from urban and industrial origin. Mutat. Res. 583(1): 67--74. (Export to RIS)
FlyBase ID	FBrf0188137
Publication Type	Research paper
PubMed ID	15866467
PubMed Abstract	The Caí River (Rio Grande do Sul, Brazil) is an important watercourse that receives large amounts of industrial and untreated municipal discharges in its lower course. We employed the SMART in Drosophila melanogaster to evaluate the genotoxicity of surface waters collected from Caí sites receiving direct sewage discharge: from Montenegro (Km 52) and from São Sebastião do Caí (Km 78 and 80), and from two sites under the industrial influence (Km 13.6 and 18.6). The genotoxic analysis included three collections: March, June and September 1999, which were tested at crude sample and at 50 and 25% concentrations. Considering the industrial samples from Km 18.6 and 13.6, collected in March, June and September 1999, they were characterized as not having genetic toxicity. The urban samples collected in March--Km 52, 78 and 80--showed a significant increment in the frequencies of total spots. In Km 52 and 78 the genotoxic effect was associated to both mutational and recombinational events, although for Km 80 the increases observed were mainly related to the occurrence of homologous recombination. Moreover, the Km 80 crude sample from June and all the concentrations analyzed for Km 52 in September were also able to induce mitotic recombination. These effects were only observed in the ST cross, demonstrating the genotoxins present in the urban discharges act by direct interaction with the DNA of the somatic cells. The SMART in D. melanogaster was shown to be highly sensitive to detect genotoxic agents present in the aquatic environment, and must be better exploited for monitoring areas under anthropogenic discharges.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Mutat. Res.
Title	Mutation Research
Publication Year	1964-
ISBN/ISSN	0027-5107
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	flr mwh