Reference Report

Reference
Citation	Wawersik, M., Milutinovich, A., Casper, A.L., Matunis, E., Williams, B., Van Doren, M. (2005). Somatic control of germline sexual development is mediated by the JAK/STAT pathway. Nature 436(7050): 563--567. (Export to RIS)
FlyBase ID	FBrf0188143
Publication Type	Research paper
PubMed ID	16049490
PubMed Abstract	Germ cells must develop along distinct male or female paths to produce the sperm or eggs required for sexual reproduction. In both mouse and Drosophila, the sexual identity of germ cells is influenced by the sex of the surrounding somatic tissue (for example, refs 1, 2, reviewed in refs 3, 4); however, little is known about how the soma controls germline sex determination. Here we show that the janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway provides a sex-specific signal from the soma to the germ line in Drosophila embryonic gonads. The somatic gonad expresses a JAK/STAT ligand, unpaired (upd), in a male-specific manner, and activates the JAK/STAT pathway in male germ cells at the time of gonad formation. Furthermore, the JAK/STAT pathway is necessary for male-specific germ cell behaviour during early gonad development, and is sufficient to activate aspects of male germ cell behaviour in female germ cells. Our findings provide direct evidence that the JAK/STAT pathway mediates a key signal from the somatic gonad that regulates male germline sexual development.
DOI
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Nature
Title	Nature
Publication Year	1869-
ISBN/ISSN	0028-0836
Data from Reference
Aberrations (1)
	Df(1)os1A2
Alleles (18)
	dsx¹ dsx^D Ecol\lacZ^esg-A507.2M2 Ecol\lacZ^{Stat92E-06346} eya^cli-IID Hmgcr^clb1 hop^Tum.Scer\UAS os^Scer\UAS.cZa os^upd-4 Scer\GAL4^how-24B Scer\GAL4^{nos.UTR.T:Hsim\VP16} Scer\GAL4^twi.PB Socs36E^{Scer\UAS.P\T.cCa} Stat92E⁰⁶³⁴⁶ tra^Scer\UAS.cFa upd2^Scer\UAS.cWa upd3^Scer\UAS.cWa wun^CE
Constructs (8)
	P{GAL4::VP16-nos.UTR} P{GAL4-twi.B} P{UAS-hop.Tum} P{UAS-os.Z} P{UASp-Socs36E.C} P{UAS-tra.F} P{UAS-upd2.W} P{UAS-upd3.W}
Genes (20)
	dpa dsx Ecol\lacZ en eya His3 Hmgcr hop Mcm5 os Scer\GAL4 Socs36E Sox100B Stat92E Sxl tra upd2 upd3 vas wun
Insertions (3)
	P{GawB}how^24B P{lArB}A507.2M2 P{PZ}Stat92E⁰⁶³⁴⁶
Natural transposons (1)
	P-element