Reference Report

Reference
Citation	Becam, I.E., Tanentzapf, G., Lepesant, J.A., Brown, N.H., Huynh, J.R. (2005). Integrin-independent repression of cadherin transcription by talin during axis formation in Drosophila. Nat. Cell Biol. 7(5): 510--516. (Export to RIS)
FlyBase ID	FBrf0188145
Publication Type	Research paper
PubMed ID	15852002
PubMed Abstract	The Drosophila melanogaster anterior-posterior axis becomes polarized early during oogenesis by the posterior localization of the oocyte within the egg chamber. The invariant position of the oocyte is thought to be driven by an upregulation of the adhesion molecule DE-cadherin in the oocyte and the posterior somatic follicle cells, providing the first in vivo example of cell sorting that is specified by quantitative differences in cell-cell adhesion. However, it has remained unclear how DE-cadherin levels are regulated. Here, we show that talin, known for its role in linking integrins to the actin cytoskeleton, has the unexpected function of specifically inhibiting DE-cadherin transcription. Follicle cells that are mutant for talin show a strikingly high level of DE-cadherin, due to elevated transcription of DE-cadherin. We demonstrate that this deregulation of DE-cadherin is sufficient to attract the oocyte to lateral and anterior positions. Surprisingly, this function of talin is independent of integrins. These results uncover a new role for talin in regulating cadherin-mediated cell adhesion.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Nat. Cell Biol.
Title	Nature Cell Biology
Publication Year	1999-
ISBN/ISSN	1465-7392 1476-4679
Data from Reference
Aberrations (1)
	Df(3L)79a
Alleles (17)
	Ecol\lacZ^Fas3-80 Ecol\lacZ^shg-k03401 Itgβν¹ Itgβν² Itgβν^unspecified mys¹¹ rhea² rhea¹⁷ rhea^Ubi.PB rhea^unspecified Scer\GAL4^Act5C.PP Scer\GAL4^{Scer\FRT.Rnor\CD2.Act5C} shg^JH shg^R69 shg^Scer\UAS.cSa shg^{tub.T:Avic\GFP} shg^{Ubi-p63E.T:Avic\GFP-rs}
Constructs (5)
	P{GAL4-Act5C(FRT.CD2).P} P{tub-shg-GFP} P{UAS-shg.CAD} P{Ubi-p63E-shg.GFP} P{Ubi-talin.B}
Genes (12)
	aPKC baz Ecol\lacZ Fas3 Itgβν mys orb rhea Scer\GAL4 shg T:Avic\GFP α-Spec
Insertions (2)
	P{lacW}shg^k03401 P{PZ}Fas3⁸⁰
Natural transposons (1)
	P-element