Reference Report

Reference
Citation	Jenny, A., Reynolds-Kenneally, J., Das, G., Burnett, M., Mlodzik, M. (2005). Diego and Prickle regulate Frizzled planar cell polarity signalling by competing for Dishevelled binding. Nat. Cell Biol. 7(7): 691--697. (Export to RIS)
FlyBase ID	FBrf0188147
Publication Type	Research paper
PubMed ID	15937478
PubMed Abstract	Epithelial planar cell polarity (PCP) is evident in the cellular organization of many tissues in vertebrates and invertebrates. In mammals, PCP signalling governs convergent extension during gastrulation and the organization of a wide variety of structures, including the orientation of body hair and sensory hair cells of the inner ear. In Drosophila melanogaster, PCP is manifest in adult tissues, including ommatidial arrangement in the compound eye and hair orientation in wing cells. PCP establishment requires the conserved Frizzled/Dishevelled PCP pathway. Mutations in PCP-pathway-associated genes cause aberrant orientation of body hair or inner-ear sensory cells in mice, or misorientation of ommatidia and wing hair in D. melanogaster. Here we provide mechanistic insight into Frizzled/Dishevelled signalling regulation. We show that the ankyrin-repeat protein Diego binds directly to Dishevelled and promotes Frizzled signalling. Dishevelled can also be bound by the Frizzled PCP antagonist Prickle. Strikingly, Diego and Prickle compete with one another for Dishevelled binding, thereby modulating Frizzled/Dishevelled activity and ensuring tight control over Frizzled PCP signalling.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Nat. Cell Biol.
Title	Nature Cell Biology
Publication Year	1999-
ISBN/ISSN	1465-7392 1476-4679
Data from Reference
Alleles (22)
	dgo²⁶⁹ dgo³⁰⁸ dgo³⁸⁰ dgo^Scer\UAS.cFa dgo^sev.PJ dsh¹ dsh³ dsh^hs.sev.B fz¹³ fz²³ fz^hs.sev fz^Scer\UAS.cAa pk¹ pk^pk-sple-6 pk^pk-sple-13 pk^Scer\UAS.cGa Rho1^72O Rho1^79-3 Scer\GAL4^dpp.blk1 Scer\GAL4^hs.2sev Vang^Scer\UAS.cWa Vang^stbm-6
Constructs (9)
	P{GAL4-dpp.blk1} P{GAL4-Hsp70.sev} P{sE-Dsh.B} P{sev-dgo.J} P{sev-fz.T} P{UAS-dgo.F} P{UAS-fz.A} P{UAS-pk.G} P{UAS-stbm.W}
Genes (7)
	dgo dsh fz pk Rho1 Scer\GAL4 Vang
Natural transposons (1)
	P-element