Reference Report

Reference
Citation	Yuan, Q., Lin, F., Zheng, X., Sehgal, A. (2005). Serotonin modulates circadian entrainment in Drosophila. Neuron 47(1): 115--127. (Export to RIS)
FlyBase ID	FBrf0188183
Publication Type	Research paper
PubMed ID	15996552
PubMed Abstract	Entrainment of the Drosophila circadian clock to light involves the light-induced degradation of the clock protein timeless (TIM). We show here that this entrainment mechanism is inhibited by serotonin, acting through the Drosophila serotonin receptor 1B (d5-HT1B). d5-HT1B is expressed in clock neurons, and alterations of its levels affect molecular and behavioral responses of the clock to light. Effects of d5-HT1B are synergistic with a mutation in the circadian photoreceptor cryptochrome (CRY) and are mediated by SHAGGY (SGG), Drosophila glycogen synthase kinase 3beta (GSK3beta), which phosphorylates TIM. Levels of serotonin are decreased in flies maintained in extended constant darkness, suggesting that modulation of the clock by serotonin may vary under different environmental conditions. These data identify a molecular connection between serotonin signaling and the central clock component TIM and suggest a homeostatic mechanism for the regulation of circadian photosensitivity in Drosophila.
DOI
Related Publication(s)
Supplementary material	Serotonin modulates circadian entrainment in Drosophila. [FBrf0199073]
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Neuron
Title	Neuron
Publication Year	1988-
ISBN/ISSN	0896-6273
Data from Reference
Alleles (15)
	5-HT1B^{dsRNA.Scer\UAS} 5-HT1B^Scer\UAS.cYa Avic\GFP^Scer\UAS.cUa Avic\GFP^{Scer\UAS.T:SV40\nls2} cry^b cry^Scer\UAS.cDa cyc⁰¹ per^{BG.T:Ppyr\LUC} Scer\GAL4^5-HT1B.PY Scer\GAL4^elav-C155 Scer\GAL4^GMR.PF Scer\GAL4^P2.4.Pdf Scer\GAL4^tim.PE sgg^{A81T.Scer\UAS} sgg^Scer\UAS.cBa
Constructs (12)
	P{BG-luc} P{GAL4-5-HT1B.Y} P{GAL4-ninaE.GMR} P{GAL4-tim.E} P{Pdf-GAL4.P2.4} P{UAS-5-HT1B.IR} P{UAS-5-HT1B.Y} P{UAS-cry.D} P{UAS-GFP.nls} P{UAS-GFP.U} P{UAS-sgg.A81T} P{UAS-sgg.B}
Genes (9)
	5-HT1B Avic\GFP cry cyc Pdf per Scer\GAL4 sgg tim
Insertions (1)
	P{GawB}elav^C155
Natural transposons (1)
	P-element