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Citation
Melcher, C., Pankratz, M.J. (2005). Candidate gustatory interneurons modulating feeding behavior in the Drosophila brain.  PLoS Biol. 3(9): e305.
FlyBase ID
FBrf0188215
Publication Type
Research paper
Abstract
Feeding is a fundamental activity of all animals that can be regulated by internal energy status or external sensory signals. We have characterized a zinc finger transcription factor, klumpfuss (klu), which is required for food intake in Drosophila larvae. Microarray analysis indicates that expression of the neuropeptide gene hugin (hug) in the brain is altered in klu mutants and that hug itself is regulated by food signals. Neuroanatomical analysis demonstrates that hug-expressing neurons project axons to the pharyngeal muscles, to the central neuroendocrine organ, and to the higher brain centers, whereas hug dendrites are innervated by external gustatory receptor-expressing neurons, as well as by internal pharyngeal chemosensory organs. The use of tetanus toxin to block synaptic transmission of hug neurons results in alteration of food intake initiation, which is dependent on previous nutrient condition. Our results provide evidence that hug neurons function within a neural circuit that modulates taste-mediated feeding behavior.
PubMed ID
PubMed Central ID
PMC1193519 (PMC) (EuropePMC)
Related Publication(s)
Review
How fruitflies know it's time for lunch.
Anonymous, 2005, PLoS Biol. 3(9): e332 [FBrf0200113]
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    PLoS Biol.
    Title
    PLoS Biology
    Publication Year
    2003-
    ISBN/ISSN
    1545-7885 1544-9173
    Data From Reference