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Citation
Mace, K.A., Pearson, J.C., McGinnis, W. (2005). An epidermal barrier wound repair pathway in Drosophila is mediated by grainy head.  Science 308(5720): 381--385.
FlyBase ID
FBrf0188326
Publication Type
Research paper
Abstract
We used wounded Drosophila embryos to define an evolutionarily conserved pathway for repairing the epidermal surface barrier. This pathway includes a wound response enhancer from the Ddc gene that requires grainy head (grh) function and binding sites for the Grh transcription factor. At the signaling level, tyrosine kinase and extracellular signal-regulated kinase (ERK) activities are induced in epidermal cells near wounds, and activated ERK is required for a robust wound response. The conservation of this Grh-dependent pathway suggests that the repair of insect cuticle and mammal skin is controlled by an ancient, shared control system for constructing and healing the animal body surface barrier.
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Note
Cell biology. Of grainy heads and broken skins.
Harden, 2005, Science 308(5720): 364--365 [FBrf0188322]
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Science
    Title
    Science
    Publication Year
    1895-
    ISBN/ISSN
    0036-8075
    Data From Reference