Open Close
Reference
Citation
Philips, J.A., Rubin, E.J., Perrimon, N. (2005). Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection.  Science 309(5738): 1251--1253.
FlyBase ID
FBrf0188333
Publication Type
Research paper
Abstract
Certain pathogens, such as Mycobacterium tuberculosis, survive within the hostile intracellular environment of a macrophage. To identify host factors required for mycobacterial entry and survival within macrophages, we performed a genomewide RNA interference screen in Drosophila macrophage-like cells, using Mycobacterium fortuitum. We identified factors required for general phagocytosis, as well as those needed specifically for mycobacterial infection. One specific factor, Peste (Pes), is a CD36 family member required for uptake of mycobacteria, but not Escherichia coli or Staphylococcus aureus. Moreover, mammalian class B scavenger receptors (SRs) conferred uptake of bacteria into nonphagocytic cells, with SR-BI and SR-BII uniquely mediating uptake of M. fortuitum, which suggests a conserved role for class B SRs in pattern recognition and innate immunity.
PubMed ID
PubMed Central ID
Related Publication(s)
Note
Host factors in infection.
Bahcall, 2005, Nat. Genet. 37(9): 929 [FBrf0188736]
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Science
    Title
    Science
    Publication Year
    1895-
    ISBN/ISSN
    0036-8075
    Data From Reference
    Genes (7)
    Human Disease Models (1)
    Cell Lines (1)