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Citation
Casso, D.J., Tanda, S., Biehs, B., Martoglio, B., Kornberg, T.B. (2005). Drosophila signal peptide peptidase is an essential protease for larval development.  Genetics 170(1): 139--148.
FlyBase ID
FBrf0188526
Publication Type
Research paper
Abstract

We identified the Drosophila melanogaster Signal peptide peptidase gene (Spp) that encodes a multipass transmembrane aspartyl protease. Drosophila SPP is homologous to the human signal peptide peptidase (SPP) and is distantly related to the presenilins. We show that, like human SPP, Drosophila SPP can proteolyze a model signal peptide and is sensitive to an SPP protease inhibitor and that it localizes to the endoplasmic reticulum. Expression of Drosophila SPP was first apparent at germ band extension, and in late embryos it was robust in the salivary glands, proventriculus, and tracheae. Flies bearing mutations in conserved residues or carrying deficiencies for the Spp gene had defective tracheae and died as larvae.

PubMed ID
PubMed Central ID
PMC1449732 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genetics
    Title
    Genetics
    Publication Year
    1916-
    ISBN/ISSN
    0016-6731
    Data From Reference
    Aberrations (2)
    Alleles (22)
    Genes (10)
    Insertions (1)
    Experimental Tools (1)
    Transgenic Constructs (7)
    Transcripts (1)