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Citation
Yao, S., Lum, L., Beachy, P. (2006). The ihog cell-surface proteins bind Hedgehog and mediate pathway activation.  Cell 125(2): 343--357.
FlyBase ID
FBrf0189929
Publication Type
Research paper
Abstract
The ihog gene (interference hedgehog), identified by RNA interference in Drosophila cultured cells, encodes a type 1 membrane protein shown here to bind and to mediate response to the active Hedgehog (Hh) protein signal. ihog mutations produce defects characteristic of Hh signaling loss in embryos and imaginal discs, and epistasis analysis places ihog action at or upstream of the negatively acting receptor component, Patched (Ptc). The first of two extracellular fibronectin type III (FNIII) domains of the Ihog protein mediates a specific interaction with Hh protein in vitro, but the second FNIII domain is additionally required for in vivo signaling activity and for Ihog-enhanced binding of Hh protein to cells coexpressing Ptc. Other members of the Ihog family, including Drosophila Boi and mammalian CDO and BOC, also interact with Hh ligands via a specific FNIII domain, thus identifying an evolutionarily conserved family of membrane proteins that function in Hh signal response.
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PubMed Central ID
Related Publication(s)
Review
New "hogs" in hedgehog transport and signal reception.
Wilson and Chuang, 2006, Cell 125(3): 435--438 [FBrf0193246]
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference
    Aberrations (1)
    Alleles (7)
    Gene Groups (3)
    Genes (17)
    Physical Interactions (2)
    Cell Lines (2)
    Insertions (3)