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Datar, S.A., Galloni, M., de la Cruz, A., Marti, M., Edgar, B.A., Frei, C. (2006). Mammalian cyclin D1/Cdk4 complexes induce cell growth in Drosophila.  Cell Cycle 5(6): 647--652.
FlyBase ID
FBrf0189936
Publication Type
Research paper
Abstract

The Drosophila melanogaster cyclin dependent protein kinase complex CycD/Cdk4 has been shown to regulate cellular growth (accumulation of mass) as well as proliferation (cell cycle progression). In contrast, the orthologous mammalian complex has been shown to regulate cell cycle progression, but possible functions in growth control have not been addressed directly. To test whether mammalian Cyclin D1/Cdk4 complexes are capable of driving cell growth, we expressed such a complex in Drosophila. Using assays that distinguish between mass increase and cell cycle progression, we found that this complex stimulated cell growth, like its Drosophila counterpart. Furthermore, Hif-1 prolyl hydroxylase (Hph) is required for both complexes to drive growth. Our data suggest that the growth-specific function of CycD/Cdk4 is conserved from arthropods to mammals.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell Cycle
    Title
    Cell Cycle
    Publication Year
    2002
    ISBN/ISSN
    1538-4101 1551-4005
    Data From Reference