Reference Report

Reference
Citation	Barmina, O., Gonzalo, M., McIntyre, L.M., Kopp, A. (2005). Sex- and segment-specific modulation of gene expression profiles in Drosophila. Dev. Biol. 288(2): 528--544. (Export to RIS)
FlyBase ID	FBrf0190088
Publication Type	Research paper
PubMed ID	16269142
PubMed Abstract	Homeotic and sex-determining genes control a wide range of morphological traits by regulating the expression of different target genes in different tissues. The identity of most of these target genes remains unknown, and it is not even clear what fraction of the genome is regulated in a segment- and sex-specific manner. In this report, we examine segment- and sex-specific gene expression in Drosophila pupal legs. The first and second legs in Drosophila have clearly distinguishable bristle patterns. Bristle pattern in the first leg also differs between males and females, whereas the second leg has no overt sexual dimorphism. To identify the genes responsible for these differences, we compared transcriptional profiles between male and female first and second legs during early pupal development. The extent of sexually dimorphic gene expression parallels morphological differences: over 100 genes are expressed sex specifically in the first leg, whereas no sexual differences are seen in the second leg. Segmental differences are less extensive than sexual dimorphism and involve fewer than 14 genes. We have identified a novel gene, CG13857, that is expressed exclusively in the first leg in a pattern that suggests this gene may play an important role in specifying segment- and sex-specific bristle patterns.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Biol.
Title	Developmental Biology
Publication Year	1959-
ISBN/ISSN	0012-1606
Data from Reference
Aberrations (1)
	Df(3R)dsx3
Alleles (5)
	dsx^D Ecol\lacZ^Scer\UAS.cUa Scer\GAL4^rn-GAL4-5 Scr^Scer\UAS.cAa tra^Scer\UAS.cFa
Constructs (3)
	P{UAS-lacZ.U} P{UAS-Scr.A} P{UAS-tra.F}
Genes (28)
	ana br CG1273 CG9215 CG13857 CG15336 CG32052 CG32683 cora CR31700 DLP dsx Ecol\lacZ Fs mnb Mnn1 mv nord Oatp58Da RasGAP1 rdo Scer\GAL4 Scp2 Scr sr Su(z)2 tra TwdlS
Insertions (2)
	P{GawB}rn^GAL4-5 P{GawB}rn^GAL4-13