Reference Report

Reference
Citation	Kenyon, K.L., Yang-Zhou, D., Cai, C.Q., Tran, S., Clouser, C., Decene, G., Ranade, S., Pignoni, F. (2005). Partner specificity is essential for proper function of the SIX-type homeodomain proteins Sine oculis and Optix during fly eye development. Dev. Biol. 286(1): 158--168. (Export to RIS)
FlyBase ID	FBrf0190132
Publication Type	Research paper
PubMed ID	16125693
PubMed Abstract	The development of the Drosophila visual system utilizes two members of the highly conserved Six-Homeobox family of transcription factor, Sine oculis and Optix. Although in vitro studies have detected differences in DNA-binding and interactions with some co-factors, questions remain as to what extent the activity for these two transcriptional regulators is redundant or specific in vivo. In this work, we show that the SoD mutation within the Six domain does not abolish DNA-protein interactions, but alters co-factor binding specificity to resemble that of Optix. A mutation in the same region of Optix alters its activity in vivo. We propose that the dominant mutant phenotype is primarily due to an alteration in binding properties of the Sine oculis protein and that distinct partner interactions is one important mechanism in determining significant functional differences between these highly conserved factors during eye development.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Biol.
Title	Developmental Biology
Publication Year	1959-
ISBN/ISSN	0012-1606
Data from Reference
Alleles (24)
	Ecol\lacZ^ato.5'F.9.3 Ecol\lacZ^dpp.BS3.0 Ecol\lacZ^wg-en11 Optix^D-G.Scer\UAS Optix^Scer\UAS.cKb Scer\GAL4^dpp.PS Scer\GAL4^ey.PH Scer\GAL4^GMR.PF Scer\GAL4^hs.PB so¹ so³ so⁵ so⁷ so⁹ so^AD.hs so^{D200.P257.Scer\UAS} so^D so^G66A.hs so^{G201D.Scer\UAS} so^hs.PA so^{L257P.Scer\UAS} so^Scer\UAS.cPa so^V200D.hs so^{V200D.Scer\UAS}
Constructs (17)
	P{ato-lacZ.5'F:9.3} P{BS3.0} P{dpp-GAL4.PS} P{GAL4-ey.H} P{GAL4-Hsp70.PB} P{GAL4-ninaE.GMR} P{hsp70/so} P{hs-so.AD} P{hs-so.G66A} P{hs-so.V200D} P{UAS-Optix.D-G} P{UAS-Optix.K} P{UAS-so.D200.P257} P{UAS-so.G201D} P{UAS-so.L257P} P{UAS-so.P} P{UAS-so.V200D}
Genes (14)
	ato dac dpp Ecol\lacZ elav eya gro h hh Opbp Optix Scer\GAL4 so Sobp
Insertions (3)
	P{?'A92}so⁹ P{A92}so⁷ P{en1}wg^en11
Natural transposons (1)
	P-element