Reference Report

Reference
Citation	Layden, M.J., Odden, J.P., Schmid, A., Garces, A., Thor, S., Doe, C.Q. (2006). Zfh1, a somatic motor neuron transcription factor, regulates axon exit from the CNS. Dev. Biol. 291(2): 253--263. (Export to RIS)
FlyBase ID	FBrf0190136
Publication Type	Research paper
PubMed ID	16458285
PubMed Abstract	Motor neurons are defined by their axon projections, which exit the CNS to innervate somatic or visceral musculature, yet remarkably little is known about how motor axons are programmed to exit the CNS. Here, we describe the role of the Drosophila Zfh1 transcription factor in promoting axon exit from the CNS. Zfh1 is detected in all embryonic somatic motor neurons, glia associated with the CNS surface and motor axons, and one identified interneuron. In zfh1 mutants, ventral projecting motor axons often stall at the edge of the CNS, failing to enter the muscle field, despite having normal motor neuron identity. Conversely, ectopic Zfh1 induces a subset of interneurons--all normally expressing two or more "ventral motor neuron transcription factors" (e.g. Islet, Hb9, Nkx6, Lim3)--to project laterally and exit the CNS. We conclude that Zfh1 is required for ventral motor axon exit from the CNS.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Biol.
Title	Developmental Biology
Publication Year	1959-
ISBN/ISSN	0012-1606
Data from Reference
Alleles (20)
	Avic\GFP^E.Scer\UAS Avic\GFP^{EGFP.nls.Scer\UAS.T:Hsap\MYC} Btau\MAPT^{isl.H.T:Hsap\MYC} Ecol\lacZ^{ap.C.T:Btau\MAPT} exex^KK30 HGTX^D25 Lim3² Scer\GAL4^22B Scer\GAL4^eg-Mz360 Scer\GAL4^elav-C155 Scer\GAL4^s.gcm Scer\GAL4^sca-109-68 tkv^{Q199D.Scer\UAS} tup¹ w^+mC zfh1² zfh1⁵ zfh1^75.26 zfh1^hs.PL zfh1^Scer\UAS.cLa
Constructs (8)
	P{apC-tau-lacZ} P{hsp70-zfh-1} P{islH-tau-myc} P{sgcm-GAL4} P{UAS-EGFP} P{UAS-nls-myc-EGFP} P{UAS-tkv.Q199D.C} P{UAS-zfh1.L}
Genes (18)
	ap Avic\GFP Btau\MAPT Ecol\lacZ eve exex Fas2 Fas3 HGTX Lim3 Mad odd repo Scer\GAL4 tkv tup w zfh1
Insertions (4)
	P{GAL4}22B P{GawB}eg^Mz360 P{GawB}elav^C155 P{GawB}sca^109-68
Natural transposons (1)
	P-element