Reference Report

Reference
Citation	Mohit, P., Makhijani, K., Madhavi, M.B., Bharathi, V., Lal, A., Sirdesai, G., Reddy, V.R., Ramesh, P., Kannan, R., Dhawan, J., Shashidhara, L.S. (2006). Modulation of AP and DV signaling pathways by the homeotic gene Ultrabithorax during haltere development in Drosophila. Dev. Biol. 291(2): 356--367. (Export to RIS)
FlyBase ID	FBrf0190145
Publication Type	Research paper
PubMed ID	16414040
PubMed Abstract	Suppression of wing fate and specification of haltere fate in Drosophila by the homeotic gene Ultrabithorax is a classical example of Hox regulation of serial homology (Lewis, E.B. 1978. Nature 276, 565-570) and has served as a paradigm for understanding homeotic gene function. We have used DNA microarray analyses to identify potential targets of Ultrabithorax function during haltere specification. Expression patterns of 18 validated target genes and functional analyses of a subset of these genes suggest that down-regulation of both anterior-posterior and dorso-ventral signaling is critical for haltere fate specification. This is further confirmed by the observation that combined over-expression of Decapentaplegic and Vestigial is sufficient to override the effect of Ubx and cause dramatic haltere-to-wing transformations. Our results also demonstrate that analysis of the differential development of wing and haltere is a good assay system to identify novel regulators of key signaling pathways.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Biol.
Title	Developmental Biology
Publication Year	1959-
ISBN/ISSN	0012-1606
Data from Reference
Alleles (24)
	Avic\GFP^Scer\UAS.cUa CG17278^{dsRNA.Sym.Scer\UAS} CG17278^Scer\UAS.cMa Cyp310a1^{dsRNA.Sym.Scer\UAS} Cyp310a1^Scer\UAS.cMa Dl^Scer\UAS.cHa dpp^Scer\UAS.cFa dsh^Scer\UAS.cNa E(spl)m8-HLH^Scer\UAS.cGa Ecol\lacZ^crb-j1B5 Ecol\lacZ^Dad-j1E4 Ecol\lacZ^{E(spl).-1166+87} Ecol\lacZ^Gprk2-06936 Ecol\lacZ^tkv-k16713 Pdcd4^G93 Scer\GAL4^bi-md653 Scer\GAL4^ptc-559.1 Scer\GAL4^{Ubx-lac1-Gal4} Scer\GAL4^vg.PM sgg^Scer\UAS.cSa Ubx^Cbx-Hm Ubx^lac1-GAL4 Ubx^Scer\UAS.cCa vg^Scer\UAS.cKa
Constructs (14)
	P{GAL4-vg.M} P{m8-lacZ} P{Sym-UAS-CG17278} P{Sym-UAS-Cyp310a1} P{UAS-CG17278.M} P{UAS-Cyp310a1.M} P{UAS-Dl.H} P{UAS-dpp.BEH1} P{UAS-dsh.N} P{UAS-E(spl)} P{UAS-GFP.U} P{UAS-sgg.S} P{UAS-Ubx.Ia.C} P{UAS-vg.K}
Genes (32)
	Avic\GFP CG13670 CG17278 CG42807 CG42808 cnc Cpr47Ee crb Cyp310a1 Dad Dl dpp dsh E(spl)m6-BFM E(spl)m8-HLH Ecol\lacZ glec Gprk2 kn Ocho osp pAbp Pdcd4 Scer\GAL4 sgg tkv toe twi Ubx Vang vg wg
Insertions (8)
	P{GawB}bi^md653 P{GawB}ptc^559.1 P{GawB}Ubx^lac1-GAL4 P{lacW}crb^j1B5 P{lacW}Dad^j1E4 P{lacW}tkv^k16713 P{PTT-GB}Pdcd4^G93 P{PZ}Gprk2⁰⁶⁹³⁶
Natural transposons (1)
	P-element