Reference Report

Reference
Citation	Rodriguez Moncalvo, V.G., Campos, A.R. (2005). Genetic dissection of trophic interactions in the larval optic neuropil of Drosophila melanogaster. Dev. Biol. 286(2): 549--558. (Export to RIS)
FlyBase ID	FBrf0190156
Publication Type	Research paper
PubMed ID	16168982
PubMed Abstract	The larval visual system of Drosophila melanogaster consists of two bilateral clusters of 12 photoreceptors, which express Rhodopsin 5 and 6 (Rh5 and Rh6) in a non-overlapping manner. These neurons send their axons in a fascicle, the larval optic nerve (LON), which terminates in the larval optic neuropil. The LON is required for the development of a serotonergic arborization originating in the central brain and for the development of the dendritic tree of the circadian pacemakers, the small ventral lateral neurons (LNv) [Malpel, S., Klarsfeld, A., Rouyer, F., 2002. Larval optic nerve and adult extra-retinal photoreceptors sequentially associate with clock neurons during Drosophila brain development. Development 129, 1443-1453; Mukhopadhyay, M., Campos, A.R., 1995. The larval optic nerve is required for the development of an identified serotonergic arborization in Drosophila melanogaster. Dev. Biol., 169, 629-643]. Here, we show that both Rh5- and Rh6-expressing fibers overlap equally with the 5-HT arborization and that it, in turn, also contacts the dendritic tree of the LNv. The experiments described here aimed at determining whether Rh5- or Rh6-expressing fibers, as well as the LNv, influence the development of this serotonergic arborization. We conclude that Rh6-expressing fibers play a unique role in providing a signal required for the outgrowth and branching of the serotonergic arborization. Moreover, the innervation of the larval optic neuropil by the 5-HT arborization depends on intact Rac function. A possible role for these serotonergic processes in modulating the larval circadian rhythmicity and photoreceptor function is discussed.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Biol.
Title	Developmental Biology
Publication Year	1959-
ISBN/ISSN	0012-1606
Data from Reference
Alleles (15)
	Ctet\TeTxLC^{IMPTNT-V.Scer\UAS} Ctet\TeTxLC^TNT.Scer\UAS Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Rac1^J11 Rac2^Δ rpr^Scer\UAS.cZa Scer\GAL4^Ddc.PL Scer\GAL4^GMR.PF Scer\GAL4^P2.4.Pdf Scer\GAL4^Rh5.PT Scer\GAL4^Rh6.PD Sh^{EKO.Scer\UAS.T:Avic\GFP-GL} T:Avic\GFP^GL W^GMR.PG W^Scer\UAS.cZa
Constructs (12)
	P{Ddc-GAL4.L} P{GAL4-ninaE.GMR} P{GMR-hid} P{Pdf-GAL4.P2.4} P{Rh5-GAL4} P{Rh6-GAL4.D} P{UAS-EKO⁺} P{UAS-mCD8::GFP.L} P{UAS-rpr.Z} P{UAS-TeTxLC.(-)V} P{UAS-TeTxLC.tnt} P{UAS-W.Z}
Genes (13)
	chp Ctet\TeTxLC Mmus\Cd8a Pdf Rac1 Rac2 Rh5 Rh6 rpr Scer\GAL4 Sh T:Avic\GFP W
Transcripts (4)
	Scer\GAL4^Ddc.PLRA Scer\GAL4^P2.4.PdfRA Scer\GAL4^Rh5.PTRA Scer\GAL4^Rh6.PDRA