Reference Report

Reference
Citation	Sykes, P.A., Condron, B.G. (2005). Development and sensitivity to serotonin of Drosophila serotonergic varicosities in the central nervous system. Dev. Biol. 286(1): 207--216. (Export to RIS)
FlyBase ID	FBrf0190167
Publication Type	Research paper
PubMed ID	16122730
PubMed Abstract	Serotonin is a classical small-molecule neurotransmitter with known effects on developmental processes. Previous studies have shown a developmental role for serotonin in the fly peripheral nervous system. In this study, we show that serotonin can modulate the development of serotonergic varicosities within the fly central nervous system. We have developed a system to examine the development of serotonergic varicosities in the larval CNS. We use this method to describe the normal serotonergic development in the A7 abdominal ganglion. From first to third instar larvae, the volume of the neuropil and number of serotonergic varicosities increase substantially while the varicosity density remains relatively constant. We hypothesize that serotonin is an autoregulator for serotonergic varicosity density. We tested the sensitivity of serotonergic varicosities to serotonin by adding neurotransmitter at various stages to isolated larval ventral nerve cords. Addition of excess exogenous serotonin decreases native varicosity density in older larvae, and these acute effects are reversible. The effects of serotonin appear to be selective for serotonergic varicosities, as dopaminergic and corazonergic varicosities remain qualitatively intact following serotonin application.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Biol.
Title	Developmental Biology
Publication Year	1959-
ISBN/ISSN	0012-1606
Data from Reference
Alleles (7)
	Ddc^k02104 eg^Mz360 Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} n-syb^{Scer\UAS.T:Avic\GFP-EGFP} Scer\GAL4^Ddc.PL Scer\GAL4^ple.PF T:Avic\GFP^EGFP
Constructs (4)
	P{Ddc-GAL4.L} P{ple-GAL4.F} P{UAS-mCD8::GFP.L} P{UAS-n-syb.eGFP}
Genes (6)
	Ddc eg Mmus\Cd8a n-syb Scer\GAL4 T:Avic\GFP
Insertions (2)
	P{GawB}eg^Mz360 P{lacW}Ddc^k02104