Reference Report

Reference
Citation	Terry, N.A., Tulina, N., Matunis, E., DiNardo, S. (2006). Novel regulators revealed by profiling Drosophila testis stem cells within their niche. Dev. Biol. 294(1): 246--257. (Export to RIS)
FlyBase ID	FBrf0190169
Publication Type	Research paper
PubMed ID	16616121
PubMed Abstract	Stem cells are defined by the fact that they both self-renew, producing additional stem cells, and generate lineal descendants that differentiate into distinct functional cell types. In Drosophila, a small germline stem cell population is influenced by a complex microenvironment, the stem cell niche, which itself includes a somatic stem cell population. While stem cells are unique, their immediate descendants retain considerable stem cell character as they mitotically amplify prior to differentiation and can be induced to de-differentiate into stem cells. Despite their importance, very few genes are known that are expressed in the stem cells or their early amplifying daughters. We present here whole-genome microarray expression analysis of testes specifically enriched for stem cells, their amplifying daughters, and their niche. These studies have identified a number of loci with highly specific stem cell expression and provide candidate downstream targets of Jak/Stat self-renewal signaling. Furthermore, functional analysis for two genes predicted to be enriched has enabled us to define novel regulators of the germline lineage. The gene list generated in this study thus provides a potent resource for the investigation of stem cell identity and regulation from functional as well as evolutionary perspectives.
DOI	10.1016/j.ydbio.2006.02.048
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Biol.
Title	Developmental Biology
Publication Year	1959-
ISBN/ISSN	0012-1606
Data from Reference
Alleles (12)
	bgcn^QS2 Ecol\lacZ^esg-M5-4 Ecol\lacZ^fng-35UZ-1 Ecol\lacZ^kek1-15A6 Ecol\lacZ^neur-A101 neur¹ neur¹¹ os^Scer\UAS.cZa Scer\GAL4^Kr.PM Scer\GAL4^{nos.UTR.T:Hsim\VP16} Socs36E^{Scer\UAS.P\T.cCa} Socs36E^{SH2.Scer\UAS.P\T}
Constructs (5)
	P{GAL4::VP16-nos.UTR} P{GAL4-Kr.C} P{UAS-os.Z} P{UASp-Socs36E.C} P{UASp-Socs36E.SH2}
Genes (30)
	aop apt bgcn bnb br CadN CG2003 CG4269 Ecol\lacZ Fas2 Fas3 fng hipk hts Imp ImpL2 kek1 magu Mes2 miple2 neur Nrt os Rcd1 Scer\GAL4 Socs36E spi stai vas Wnt4
Insertions (4)
	P{35UZ}fng^35UZ-1 P{lArB}kek1^15A6 P{lArB}neur^A101 P{PZ}esg^M5-4