Reference Report

Reference
Citation	Wildonger, J., Mann, R.S. (2005). Evidence that nervy, the Drosophila homolog of ETO/MTG8, promotes mechanosensory organ development by enhancing Notch signaling. Dev. Biol. 286(2): 507--520. (Export to RIS)
FlyBase ID	FBrf0190182
Publication Type	Research paper
PubMed ID	16168983
PubMed Abstract	In the imaginal tissue of developing fruit flies, achaete (ac) and scute (sc) expression defines a group of neurally-competent cells called the proneural cluster (PNC). From the PNC, a single cell, the sensory organ precursor (SOP), is selected as the adult mechanosensory organ precursor. The SOP expresses high levels of ac and sc and sends a strong Delta (Dl) signal, which activates the Notch (N) receptor in neighboring cells, preventing them from also adopting a neural fate. Previous work has determined how ac and sc expression in the PNC and SOP is regulated, but less is known about SOP-specific factors that promote SOP fate. Here, we describe the role of nervy (nvy), the Drosophila homolog of the mammalian proto-oncogene ETO, in mechanosensory organ formation. Nvy is specifically expressed in the SOP, where it interacts with the Ac and Sc DNA binding partner Daughterless (Da) and affects the expression of Ac and Sc targets. nvy loss- and gain-of-function experiments suggest that nvy reinforces, but is not absolutely required for, the SOP fate. We propose a model in which nvy acts downstream of ac and sc to promote the SOP fate by transiently strengthening the Dl signal emanating from the SOP.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Biol.
Title	Developmental Biology
Publication Year	1959-
ISBN/ISSN	0012-1606
Data from Reference
Aberrations (1)
	Df(2L)da¹⁰
Alleles (26)
	ase^Scer\UAS.cBa Avic\GFP^Scer\UAS.cUa da¹⁰ da^Scer\UAS.cGa Dl^A326.2F3 Dl^B2 Dl^CS20 Ecol\lacZ^ac.AS1.4DC Ecol\lacZ^miniEx4.E1 Ecol\lacZ^sc.SRV.E1 Ecol\lacZ^sc.SRV N^XK11 nct^R46 nvy^{dsRNA.Scer\UAS} nvy^PDFKG1 nvy^Scer\UAS.cWa nvy^{Scer\UAS.T:Hsim\VP16} nvy^{δZF.Scer\UAS} sc^Scer\UAS.cPa Scer\GAL4^{neur-GAL4-A101} Scer\GAL4^pnr-MD237 Scer\GAL4^sca-537.4 Scer\GAL4^sca-C253 Scer\GAL4^αTub84B.PZ sens^Scer\UAS.cNa w^+mC
Constructs (14)
	P{ac-lacZ.AS1.4DC} P{sc-lacZ.E1} P{sc-lacZ.miniEx4.E1} P{sc-lacZ.SRV} P{UAS-ase.B} P{UAS-da.G} P{UAS-GFP.U} P{UAS-nvy.dsRNA} P{UAS-nvy.VP16} P{UAS-nvy.W} P{UAS-nvy.δZF} P{UAS-sc.P} P{UAS-sens.N} P{αTub84B(-FRT)GAL4.Z}
Genes (17)
	ac ase Avic\GFP da Dl Ecol\lacZ elav futsch N nct nvy pros sc Scer\GAL4 sens T:Hsim\VP16 w
Insertions (5)
	P{GawB}C253 P{GawB}neur^GAL4-A101 P{GawB}pnr^MD237 P{GawB}sca^537.4 P{lArB}Dl^A326.2F3
Natural transposons (1)
	P-element