Reference Report

Reference
Citation	Borghese, L., Fletcher, G., Mathieu, J., Atzberger, A., Eades, W.C., Cagan, R.L., Rorth, P. (2006). Systematic analysis of the transcriptional switch inducing migration of border cells. Dev. Cell 10(4): 497--508. (Export to RIS)
FlyBase ID	FBrf0190194
Publication Type	Research paper
PubMed ID	16580994
PubMed Abstract	Cell migration within a natural context is tightly controlled, often by specific transcription factors. However, the switch from stationary to migratory behavior is poorly understood. Border cells perform a spatially and temporally controlled invasive migration during Drosophila oogenesis. Slbo, a C/EBP family transcriptional activator, is required for them to become migratory. We purified wild-type and slbo mutant border cells as well as nonmigratory follicle cells and performed comparative whole-genome expression profiling, followed by functional tests of the contributions of identified targets to migration. About 300 genes were significantly upregulated in border cells, many dependent on Slbo. Among these, the microtubule regulator Stathmin was strongly upregulated and was required for normal migration. Actin cytoskeleton regulators were also induced, including, surprisingly, a large cluster of "muscle-specific" genes. We conclude that Slbo induces multiple cytoskeletal effectors, and that each contributes to the behavioral changes in border cells.
DOI	10.1016/j.devcel.2006.02.004
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Cell
Title	Developmental Cell
Publication Year	2001-
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Data from Reference
Aberrations (1)
	Df(2L)stai^L27
Alleles (24)
	aop¹ aop^PBac104 Arpc4^tub.PB Mhc¹ Mhc³ Mlc2^E38 qua¹ rols^T627 Scer\GAL4^c323a Scer\GAL4^c522 Scer\GAL4^slbo.2.6 Six4²⁸⁹ Six4^{Scer\UAS.T:Ivir\HA1} slbo⁰¹³¹⁰ slbo^e7b slbo^ry8ex2d sn^36a stai^{dsRNA.Scer\UAS.WIZ} stai^exC stai^Scer\UAS.cBa stai^tub.PB Tm2³ up¹⁰¹ vri²
Constructs (6)
	P{GAL4-slbo.2.6} P{tub-Arpc4.B} P{tub-stai.B} P{UAS-HA-Six4} P{UAS-stai.B} P{UAS-stai.WIZ}
Genes (39)
	Act42A Act57B aop Arpc4 bt CG9175 CG9222 CG9629 CG13101 CG31642 CG42730 eya Fas3 Gel Hex-C mbc Mhc Mlc1 Mlc2 Mp20 qua rols rost Scer\GAL4 Six4 slbo sn spir sqh stai Stat92E T:Ivir\HA1 tectonic Tm2 TpnC73F up vri WDR79 zip
Insertions (3)
	P{GawB}c323a P{GawB}c522 P{GSV1}stai^GS2209
Natural transposons (1)
	P-element