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Citation
Kirilly, D., Spana, E.P., Perrimon, N., Padgett, R.W., Xie, T. (2005). BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary.  Dev. Cell 9(5): 651--662.
FlyBase ID
FBrf0190209
Publication Type
Research paper
Abstract
BMP signaling is essential for promoting self-renewal of mouse embryonic stem cells and Drosophila germline stem cells and for repressing stem cell proliferation in the mouse intestine and skin. However, it remains unknown whether BMP signaling can promote self-renewal of adult somatic stem cells. In this study, we show that BMP signaling is necessary and sufficient for promoting self-renewal and proliferation of somatic stem cells (SSCs) in the Drosophila ovary. BMP signaling is required in SSCs to directly control their maintenance and division, but is dispensable for proliferation of their differentiated progeny. Furthermore, BMP signaling is required to control SSC self-renewal, but not survival. Moreover, constitutive BMP signaling prolongs the SSC lifespan. Therefore, our study clearly demonstrates that BMP signaling directly promotes SSC self-renewal and proliferation in the Drosophila ovary. Our work further suggests that BMP signaling could promote self-renewal of adult stem cells in other systems.
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PubMed Central ID
Related Publication(s)
Supplementary material
Review
BMPs promote the self renewal of somatic stem cells.
Kruger, 2005, Cell 123(7): 1165 [FBrf0198679]
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Cell
    Title
    Developmental Cell
    Publication Year
    2001-
    ISBN/ISSN
    1534-5807 1878-1551
    Data From Reference