Reference Report

Reference
Citation	Mandal, S., Guptan, P., Owusu-Ansah, E., Banerjee, U. (2005). Mitochondrial regulation of cell cycle progression during development as revealed by the tenured mutation revealed in Drosophila. Dev. Cell 9(6): 843--854. (Export to RIS)
FlyBase ID	FBrf0190213
Publication Type	Research paper
PubMed ID	16326395
PubMed Abstract	The precise control of the cell cycle requires regulation by many intrinsic and extrinsic factors. Whether the metabolic status of the cell exerts a direct control over cell cycle checkpoints is not well understood. We isolated a mutation, tenured (tend), in a gene encoding cytochrome oxidase subunit Va. This mutation causes a drop in intracellular ATP to levels sufficient to maintain cell survival, growth, and differentiation, but not to enable progression through the cell cycle. Analysis of this gene in vivo and in cell lines shows that a specific pathway involving AMPK and p53 is activated that causes elimination of Cyclin E, resulting in cell cycle arrest. We demonstrate that in multiple tissues the mitochondrion has a direct and specific role in enforcing a G1-S cell cycle checkpoint during periods of energy deprivation.
DOI
Related Publication(s)
Note	Genetic studies of the Drosophila eye link energy metabolism with cell-cycle progression. Thummel, 2011, Dev. Cell 21(6): e1 [FBrf0217010]
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Dev. Cell
Title	Developmental Cell
Publication Year	2001-
ISBN/ISSN
Data from Reference
Alleles (11)
	CoVa^+t1.925 CoVa^dsRNA.cMa CoVa^tend CycE^hs.II mRpL4^k14608 mRpL17^KG06809 p53^11-1B-1 Pdsw^k10101 RpS3^unspecified SNF4Aγ^KG00325 Tor^ΔP
Constructs (2)
	P{CoVa⁺t1.925} P{hs-CycE.II}
Genes (19)
	ato B-H1 ci CoVa ct CycA CycB CycD CycE dap elav lz mRpL4 mRpL17 p53 Pdsw RpS3 SNF4Aγ Tor
Insertions (5)
	P{GT1}CG14722^BG01876 P{lacW}mRpL4^k14608 P{lacW}Pdsw^k10101 P{SUPor-P}KG03257 P{SUPor-P}mRpL17^KG06809
Natural transposons (1)
	P-element