Reference Report

Reference
Citation	Moon, N.S., Frolov, M.V., Kwon, E.J., Di Stefano, L., Dimova, D.K., Morris, E.J., Taylor-Harding, B., White, K., Dyson, N.J. (2005). Drosophila E2F1 has context-specific pro- and antiapoptotic properties during development. Dev. Cell 9(4): 463--475. (Export to RIS)
FlyBase ID	FBrf0190216
Publication Type	Research paper
PubMed ID	16198289
PubMed Abstract	E2F transcription factors are generally believed to be positive regulators of apoptosis. In this study, we show that dE2F1 and dDP are important for the normal pattern of DNA damage-induced apoptosis in Drosophila wing discs. Unexpectedly, the role that E2F plays varies depending on the position of the cells within the disc. In irradiated wild-type discs, intervein cells show a high level of DNA damage-induced apoptosis, while cells within the D/V boundary are protected. In irradiated discs lacking E2F regulation, intervein cells are largely protected, but apoptotic cells are found at the D/V boundary. The protective effect of E2F at the D/V boundary is due to a spatially restricted role in the repression of hid. These loss-of-function experiments demonstrate that E2F cannot be classified simply as a pro- or antiapoptotic factor. Instead, the overall role of E2F in the damage response varies greatly and depends on the cellular context.
DOI
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Dev. Cell
Title	Developmental Cell
Publication Year	2001-
ISBN/ISSN
Data from Reference
Aberrations (2)
	Df(3L)X14 Df(3L)XR38
Alleles (25)
	Ark^CD4 Dp^a2 Dp^a4 E2f2^76Q1 E2f2³²⁹ E2f2^dsRNA.cSa E2f2^g5 E2f⁹¹ E2f^dsRNA.cFa E2fⁱ² E2f^rM729 E2f^su89 Mpp6^+t4 N^ICN.Scer\UAS Ppyr\LUC^{mus209.5'-168.hidE2f} Ppyr\LUC^{mus209.5'-168.mutI.II.hidE2F} Ppyr\LUC^{mus209.5'-168.mutI.II} Ppyr\LUC^{mus209.5'-168} Ras85D^V12.Scer\UAS Rbf^dsRNA.cFa Rbf^Δ14 Scer\GAL4^Act5C.PI Scer\GAL4^en-e16E Scer\GAL4^{Scer\FRT.Act5C} W⁰⁵⁰¹⁴
Constructs (5)
	P{Act5C-GAL4} P{AyGAL4} P{Mpp6^+t4} P{UAS-N.ICN} P{UAS-Ras85D.V12}
Genes (16)
	Ark bs Dcp-1 Dl Dp E2f E2f2 His3 Mpp6 N Ppyr\LUC Ras85D Rbf RnrS Scer\GAL4 W
Insertions (1)
	P{en2.4-GAL4}e16E