Reference Report

Reference
Citation	Thompson, B.J., Mathieu, J., Sung, H.H., Loeser, E., Rorth, P., Cohen, S.M. (2005). Tumor suppressor properties of the ESCRT-II complex component Vps25 in Drosophila. Dev. Cell 9(5): 711--720. (Export to RIS)
FlyBase ID	FBrf0190222
Publication Type	Research paper
PubMed ID	16256745
PubMed Abstract	We have found that the Drosophila gene vps25 possesses several properties of a tumor suppressor. First, vps25 mutant cells activate Notch and Dpp receptor signaling, inducing ectopic organizers in developing eyes and limbs and consequent overproliferation of both mutant and nearby wild-type cells. Second, as the mutant cells proliferate, they lose their epithelial organization and undergo apoptosis. Strikingly, when apoptosis of mutant cells is blocked, tumor-like overgrowths are formed that are capable of metastasis. vps25 encodes a component of the ESCRT-II complex, which sorts membrane proteins into multivesicular bodies during endocytic trafficking to the lysosome. Activation of Notch and Dpp receptor signaling in mutant cells results from an endocytic blockage that causes accumulation of these receptors and other signaling components in endosomes. These results highlight the importance of endocytic trafficking in regulating signaling and epithelial organization and suggest a possible role for ESCRT components in human cancer.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Cell
Title	Developmental Cell
Publication Year	2001-
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Data from Reference
Alleles (8)
	Avic\GFP^{Scer\UAS.T:Hsap\MYC,T:Mmus\2xFYVE} BacA\p35^Scer\UAS.cHa Ecol\lacZ^bi-Pol-1 Ecol\lacZ^dpp.BS3.0 Scer\GAL4^αTub84B.PL Scer\GAL80^αTub84B.PL Vps25^k08904 Vps25^Pb2931
Constructs (6)
	P{BS3.0} P{tubP-GAL4} P{tubP-GAL80} P{UAS-GFP-myc-2xFYVE} P{UAS-p35.H} PBac{PB}
Genes (12)
	Avic\GFP BacA\p35 bi dpp Ecol\lacZ N os Scer\GAL4 Scer\GAL80 tkv Vps25 wg
Insertions (2)
	P{lacW}bi^Pol-1 PBac{PB}Vps25^Pb2931