Reference Report

Reference
Citation	Zhang, T., Tran, S., Clouser, C., Pignoni, F. (2005). Nicastrin controls aspects of photoreceptor neuron specification and differentiation in the Drosophila eye. Dev. Dyn. 234(3): 590--601. (Export to RIS)
FlyBase ID	FBrf0190251
Publication Type	Research paper
PubMed ID	16145661
PubMed Abstract	Nicastrin is a component of the Notch signaling pathway involved in proteolytic release of the Notch receptor intracellular domain. It has been postulated that intracellular Notch is required within the nucleus of fly eye progenitor cells to enhance (pro-neural enhancement) and then repress (lateral inhibition) transcription of pro-neural genes. We present here an analysis of Nicastrin function during eye development and find that Nicastrin is essential to early photoreceptor neuron development. Nicastrin mutant tissue displays neuronal loss or hyperplasia; these phenotypes can be rescued by targeted expression of an intracellular form of Notch. Thus, nuclear translocation of Notch and its direct regulation of gene expression appear to be critical to pro-neural enhancement as well as lateral inhibition. In addition, we show that Nicastrin as well as Notch are required to maintain normal R-cell morphology, because the nuclei of mutant photoreceptor neurons cannot maintain their proper position. Thus, Notch signaling plays a role, not only in cell fate specification, but also in differentiation of photoreceptor neurons.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Dyn.
Title	Developmental Dynamics
Publication Year	1992-
ISBN/ISSN	1058-8388
Data from Reference
Aberrations (4)
	Df(1)N-54l9 Df(3R)96B Df(3R)96ST Df(3R)XTA1
Alleles (9)
	Ecol\lacZ^dpp.BS3.0 N^{int.U.Scer\UAS} N^l1N-ts1 nct^ST1 nct^ST2 nct^ST3 nct^ST4 Scer\GAL4^dpp.blk1 Scer\GAL4^GMR.PF
Constructs (4)
	P{BS3.0} P{GAL4-dpp.blk1} P{GAL4-ninaE.GMR} P{UAS-N.intra.U}
Genes (24)
	arm ato CG3744 CG5807 CG31357 CycB3 dac dpp Ecol\lacZ Ela elav Esp ey eya h N nct niki Patj RabX4 Saf-B Scer\GAL4 sens sosie
Insertions (1)
	P{lacW}CycB3^L6540