Reference Report

Reference
Citation	Shapiro, R.S., Anderson, K.V. (2006). Drosophila Ik2, a member of the IκB kinase family, is required for mRNA localization during oogenesis. Development 133(8): 1467--1475. (Export to RIS)
FlyBase ID	FBrf0190320
Publication Type	Research paper
PubMed ID	16540511
PubMed Abstract	In both Drosophila and mammals, IkappaB kinases (IKKs) regulate the activity of Rel/NF-kappaB transcription factors by targeting their inhibitory partner proteins, IkappaBs, for degradation. We identified mutations in ik2, the gene that encodes one of two Drosophila IKKs, and found that the gene is essential for viability. During oogenesis, ik2 is required in an NF-kappaB-independent process that is essential for the localization of oskar and gurken mRNAs; as a result, females that lack ik2 in the germline produce embryos that are both bicaudal and ventralized. The abnormal RNA localization in ik2 mutant oocytes can be attributed to defects in the organization of microtubule minus-ends. In addition, both mutant oocytes and mutant escaper adults have abnormalities in the organization of the actin cytoskeleton. These data suggest that this IkappaB kinase has an NF-kappaB-independent role in mRNA localization and helps to link microtubule minus-ends to the oocyte cortex, a novel function of the IKK family.
DOI	10.1242/dev.02318
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (1)
	Df(2L)Fs(2)Ket-RX32
Alleles (14)
	Avic\GFP^{αTub67C.S65T.I167T.T:Btau\MAPT} BicD¹ BicD² ik2¹ ik2² ik2³ ik2⁴ ik2⁵ ik2^alice Khc::nod^T:Ecol\lacZ Khc^{E97.Hsp83.T:Ecol\lacZ} ovo^D1 pip¹ pip²
Constructs (3)
	P{Khc^E97:lacZ} P{NZ} P{Tub67C-Tau-GFP}
Genes (12)
	Avic\GFP bcd BicD grk ik2 Khc Khc::nod nos osk ovo pip twi