Reference Report

Reference
Citation	Wang, J., Lee, C.H.J., Lin, S., Lee, T. (2006). Steroid hormone-dependent transformation of polyhomeotic mutant neurons in the Drosophila brain. Development 133(7): 1231--1240. (Export to RIS)
FlyBase ID	FBrf0190330
Publication Type	Research paper
PubMed ID	16495309
PubMed Abstract	Polyhomeotic (Ph), which forms complexes with other Polycomb-group (PcG) proteins, is widely required for maintenance of cell identity by ensuring differential gene expression patterns in distinct types of cells. Genetic mosaic screens in adult fly brains allow for recovery of a mutation that simultaneously disrupts the tandemly duplicated Drosophila ph transcriptional units. Distinct clones of neurons normally acquire different characteristic projection patterns and can be differentially labeled using various subtype-specific drivers in mosaic brains. Such neuronal diversity is lost without Ph. In response to ecdysone, ph mutant neurons are transformed into cells with unidentifiable projection patterns and indistinguishable gene expression profiles during early metamorphosis. Some subtype-specific neuronal drivers become constitutively activated, while others are constantly suppressed. By contrast, loss of other PcG proteins, including Pc and E(z), causes different neuronal developmental defects; and, consistent with these phenomena, distinct Hox genes are differentially misexpressed in different PcG mutant clones. Taken together, Drosophila Ph is essential for governing neuronal diversity, especially during steroid hormone signaling.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (7)
	Df(1)64c18 Df(1)MB342 Df(1)Pgd35 Df(1)Pgd-kz Dp(1;2;Y)w⁺ Dp(1;f)R Tp(1;3)w^vco
Alleles (11)
	E(z)⁷³¹ l(1)G0458^G0458 Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Pc¹⁵ ph-d^+tSa ph-p⁶⁰² Scer\GAL4^ato.3.6 Scer\GAL4^EB1 Scer\GAL4^elav.PLu Scer\GAL4^ey-OK107 Scer\GAL4^NP0225
Constructs (4)
	P{ato-GAL4.3.6} P{GAL4-elav.L} P{ph-d^+tSa} P{UAS-mCD8::GFP.L}
Genes (19)
	abd-A Abd-B Antp csw Dfd E(z) l(1)2Da l(1)G0458 lab Mmus\Cd8a pb Pc Pgd ph-d ph-p Scer\GAL4 Scr Ubx wapl
Insertions (4)
	P{GawB}EB1 P{GawB}ey^OK107 P{GawB}NP0225 P{lacW}l(1)G0458^G0458