Reference Report

Reference
Citation	Werz, C., Lee, T.V., Lee, P.L., Lackey, M., Bolduc, C., Stein, D.S., Bergmann, A. (2005). Mis-specified cells die by an active gene-directed process, and inhibition of this death results in cell fate transformation in Drosophila. Development 132(24): 5343--5352. (Export to RIS)
FlyBase ID	FBrf0190331
Publication Type	Research paper
PubMed ID	16280349
PubMed Abstract	Incorrectly specified or mis-specified cells often undergo cell death or are transformed to adopt a different cell fate during development. The underlying cause for this distinction is largely unknown. In many developmental mutants in Drosophila, large numbers of mis-specified cells die synchronously, providing a convenient model for analysis of this phenomenon. The maternal mutant bicoid is particularly useful model with which to address this issue because its mutant phenotype is a combination of both transformation of tissue (acron to telson) and cell death in the presumptive head and thorax regions. We show that a subset of these mis-specified cells die through an active gene-directed process involving transcriptional upregulation of the cell death inducer hid. Upregulation of hid also occurs in oskar mutants and other segmentation mutants. In hid bicoid double mutants, mis-specified cells in the presumptive head and thorax survive and continue to develop, but they are transformed to adopt a different cell fate. We provide evidence that the terminal torso signaling pathway protects the mis-specified telson tissue in bicoid mutants from hid-induced cell death, whereas mis-specified cells in the head and thorax die, presumably because equivalent survival signals are lacking. These data support a model whereby mis-specification can be tolerated if a survival pathway is provided, resulting in cellular transformation.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (1)
	Df(3L)H99
Alleles (13)
	BacA\p35^{Scer\UAS.P\T.cWa} bcd⁶ bcd⁷ bcd¹² bcd^unspecified osk³ osk⁶ Scer\GAL4^tub.PU tor¹ tor⁴ tor^unspecified W^hid-A329 W^rvX1
Constructs (2)
	P{tub-GAL4.U} P{UASp-p35.W}
Genes (12)
	Abd-B BacA\p35 bcd dlg1 Ice kni odd osk Scer\GAL4 tor W wg
Natural transposons (1)
	P-element