Reference Report

Reference
Citation	Kanuka, H., Kuranaga, E., Takemoto, K., Hiratou, T., Okano, H., Miura, M. (2005). Drosophila caspase transduces Shaggy/GSK-3beta kinase activity in neural precursor development. EMBO J. 24(21): 3793--3806. (Export to RIS)
FlyBase ID	FBrf0190361
Publication Type	Research paper
PubMed ID	16222340
PubMed Abstract	Caspases are well known for their role in the execution of apoptotic programs, in which they cleave specific target proteins, leading to the elimination of cells, and for their role in cytokine maturation. In this study, we identified a novel substrate, which, through cleavage by caspases, can regulate Drosophila neural precursor development. Shaggy (Sgg)46 protein, an isoform encoded by the sgg gene and essential for the negative regulation of Wingless signaling, is cleaved by the Dark-dependent caspase. This cleavage converts it to an active kinase, which contributes to the formation of neural precursor (sensory organ precursor (SOP)) cells. Our evidence suggests that caspase regulation of the wingless pathway is not associated with apoptotic cell death. These results imply a novel role for caspases in modulating cell signaling pathways through substrate cleavage in neural precursor development.
DOI
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Supplementary material	Drosophila caspase transduces Shaggy/GSK-3beta kinase activity in neural precursor development. [FBrf0191762]
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	EMBO J.
Title	The EMBO Journal
Publication Year	1982-
ISBN/ISSN	0261-4189
Data from Reference
Alleles (33)
	Ark^k11502 Avic\GFP^{SCAT3.Scer\UAS} Avic\GFP^Scer\UAS.cUa BacA\p35^Scer\UAS.cHa Dcp-1^{Scer\UAS.T:Ivir\HA1} Dredd^{Scer\UAS.T:Ivir\HA1} Ecol\lacZ^{dsRNA.IR.Scer\UAS} Ecol\lacZ^neur-A101 Ecol\lacZ^Scer\UAS.cUa Iap2^Scer\UAS.cIa Ice^{Scer\UAS.T:Ivir\HA1} Nc^{C318G.Scer\UAS} Nc^{dsRNA.Scer\UAS} Nc^{Scer\UAS.T:Ivir\HA1} rpr^hs.PW Scer\GAL4^Act5C.PHb Scer\GAL4^dpp.blk1 Scer\GAL4^hs.PB Scer\GAL4^{neur-GAL4-A101} Scer\GAL4^sca-P309 sgg^{10.Scer\UAS.T:Hsap\MYC} sgg³² sgg^{46.Scer\UAS.T:Hsap\MYC} sgg^{A81T.Scer\UAS} sgg^{D235G.D300G.Scer\UAS.T:Hsap\MYC} sgg^{D235G.Scer\UAS.T:Hsap\MYC} sgg^{D300G.Scer\UAS.T:Hsap\MYC} sgg^{dsRNA.10.Scer\UAS} sgg^{dsRNA.46.Scer\UAS} sgg^{K83R.Scer\UAS.T:Hsap\MYC} sgg^{ΔN300.Scer\UAS.T:Hsap\MYC} th^Scer\UAS.cHa wg^Sp-1
Constructs (19)
	P{GAL4-dpp.blk1} P{GAL4-Hsp70.PB} P{UAS-DIAP1.H} P{UAS-dronc.C318G} P{UAS-GFP.U} P{UAS-Iap2.I} P{UAS-lacZ.IR} P{UAS-lacZ.U} P{UAS-Nc.dsRNA} P{UAS-p35.H} P{UAS-SCAT3} P{UAS-sgg.10.MYC} P{UAS-sgg.46.MYC} P{UAS-sgg.A81T} P{UAS-sgg.dsRNA.10} P{UAS-sgg.dsRNA.46} P{UAS-sgg.MYC.D235G/D300G} P{UAS-sgg.MYC.K83R} P{UAS-sgg.MYC.ΔN300}
Genes (23)
	ac Ark arm Avic\GFP BacA\p35 Dcp-1 Dredd Ecol\lacZ elav Iap2 Ice Nc neur pros rpr sca Scer\GAL4 sens sgg T:Hsap\MYC T:Ivir\HA1 th wg
Insertions (4)
	P{GAL4}sca^P309 P{GawB}neur^GAL4-A101 P{lacW}Ark^k11502 P{lArB}neur^A101
Natural transposons (1)
	P-element