Reference Report

Reference
Citation	Zheng, X., Zugates, C.T., Lu, Z., Shi, L., Bai, J.M., Lee, T. (2006). Baboon/dSmad2 TGF-beta signaling is required during late larval stage for development of adult-specific neurons. EMBO J. 25(3): 615--627. (Export to RIS)
FlyBase ID	FBrf0190369
Publication Type	Research paper
PubMed ID	16437159
PubMed Abstract	The intermingling of larval functional neurons with adult-specific neurons during metamorphosis contributes to the development of the adult Drosophila brain. To better understand this process, we characterized the development of a dorsal cluster (DC) of Atonal-positive neurons that are born at early larval stages but do not undergo extensive morphogenesis until pupal formation. We found that Baboon(Babo)/dSmad2-mediated TGF-beta signaling, known to be essential for remodeling of larval functional neurons, is also indispensable for proper morphogenesis of these adult-specific neurons. Mosaic analysis reveals slowed development of mutant DC neurons, as evidenced by delays in both neuronal morphogenesis and atonal expression. We observe similar phenomena in other adult-specific neurons. We further demonstrate that Babo/dSmad2 operates autonomously in individual neurons and specifically during the late larval stage. Our results suggest that Babo/dSmad2 signaling prior to metamorphosis may be widely required to prepare neurons for the dynamic environment present during metamorphosis.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	EMBO J.
Title	The EMBO Journal
Publication Year	1982-
ISBN/ISSN	0261-4189
Data from Reference
Alleles (15)
	babo⁹ babo^a.Scer\UAS babo^b.Scer\UAS Dscam^{exon17.1.Scer\UAS.T:Avic\GFP} Med¹³ Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} n-syb^{Scer\UAS.cEa.T:Avic\GFP} put¹³⁵ put^Δ61 Scer\GAL4^ato.3.6 Scer\GAL4^EB1 Scer\GAL4^ey-OK107 Scer\GAL4^Tab2-201Y Smox¹ wit^G15
Constructs (6)
	P{ato-GAL4.3.6} P{UAS-babo.a} P{UAS-babo.b} P{UAS-Dscam.exon17.1.GFP} P{UAS-mCD8::GFP.L} P{UAS-n-syb-GFP.E}
Genes (12)
	ato babo Dscam EcR Med Mmus\Cd8a n-syb put Scer\GAL4 Smox T:Avic\GFP wit
Insertions (3)
	P{GawB}EB1 P{GawB}ey^OK107 P{GawB}Tab2^201Y
Natural transposons (1)
	P-element