Reference Report

Reference
Citation	Carhan, A., Allen, F., Armstrong, J.D., Goodwin, S.F., O'Dell, K.M.C. (2005). Female receptivity phenotype of icebox mutants caused by a mutation in the L1-type cell adhesion molecule neuroglian. Genes Brain Behav. 4(8): 449--465. (Export to RIS)
FlyBase ID	FBrf0190532
Publication Type	Research paper
PubMed ID	16268990
PubMed Abstract	Relatively little is known about the genes and brain structures that enable virgin female Drosophila to make the decision to mate or not. Classical genetic approaches have identified several mutant females that have a reluctance-to-mate phenotype, but most of these have additional behavioral defects. However, the icebox (ibx) mutation was previously reported to lower the sexual receptivity of females, without apparently affecting any other aspect of female behavior. We have shown that the ibx mutation maps to the 7F region of the Drosophila X chromosome to form a complex complementation group with both lethal and viable alleles of neuroglian (nrg). The L1-type cell adhesion molecule encoded by nrg consists of six immunoglobulin-like domains, five fibronectin-like domains, one transmembrane domain and one alternatively spliced intracellular domain. The ibx strain has a missense mutation causing a glycine-to-arginine change at amino acid 92 in the first immunoglobulin domain of nrg. Defects in the central brain of ibx mutants are similar to those observed in another nrg mutant, central brain deranged(1) (ceb(1)). However, both ceb(1) homozygous and ceb(1)/ibx heterozygous females are receptive. The expression of a transgene containing the non-neural isoform of nrg rescues both the receptivity and the brain structure phenotypes of ibx females.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genes Brain Behav.
Title	Genes, Brain, and Behavior
Publication Year	2002-
ISBN/ISSN	1601-1848
Data from Reference
Aberrations (6)
	Df(1)Desi-S3 Df(1)KA14 Df(1)RA2 Df(1)Sxl-bt In(1)S In(1)sc⁷
Alleles (28)
	fs(1)M112¹ gg² iav¹ IntS4^G0095 l(1)7Ed¹ l(1)ESHS38¹ l(1)G0178^G0178 lawc^EF520 Nrg^167.Scer\UAS Nrg^{180.I.Scer\UAS} Nrg⁸⁴⁹ Nrg⁸⁹² Nrg^BG01674 Nrg^G0099 Nrg^G00305 Nrg^G0413 Nrg^G0488b Nrg^ibx Nrg^l4 Nrg^l7 Nrg^l10 otu⁷ ptg⁷ Scer\GAL4^30Y Scer\GAL4^c316 Scer\GAL4^Mef2.247 Scer\GAL4^Tab2-201Y sdt^XN
Constructs (3)
	P{Mef2-GAL4.247} P{UAS-nrg¹⁶⁷} P{UAS-nrg¹⁸⁰}
Genes (16)
	brp Fas2 fs(1)M112 gg iav IntS4 l(1)7Ed l(1)ESHS38 l(1)G0178 lawc Nrg otu PIP82 ptg Scer\GAL4 sdt
Insertions (5)
	P{GawB}30Y P{GawB}c316 P{GawB}Tab2^201Y P{GT1}Nrg^BG01674 P{PTT-GA}Nrg^G00305