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Citation
Mohd-Sarip, A., Cleard, F., Mishra, R.K., Karch, F., Verrijzer, C.P. (2005). Synergistic recognition of an epigenetic DNA element by Pleiohomeotic and a Polycomb core complex.  Genes Dev. 19(15): 1755--1760.
FlyBase ID
FBrf0190555
Publication Type
Research paper
Abstract

Polycomb response elements (PREs) are cis-acting DNA elements that mediate epigenetic gene silencing by Polycomb group (PcG) proteins. Here, we report that Pleiohomeotic (PHO) and a multiprotein Polycomb core complex (PCC) bind highly cooperatively to PREs. We identified a conserved sequence motif, named PCC-binding element (PBE), which is required for PcG silencing in vivo. PHO sites and PBEs function as an integrated DNA platform for the synergistic assembly of a repressive PHO/PCC complex. We termed this nucleoprotein complex silenceosome to reflect that the molecular principles underpinning its assemblage are surprisingly similar to those that make an enhanceosome.

PubMed ID
PubMed Central ID
PMC1182336 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genes Dev.
    Title
    Genes & Development
    Publication Year
    1987-
    ISBN/ISSN
    0890-9369
    Data From Reference
    Alleles (3)
    Genes (7)
    Natural transposons (1)
    Transgenic Constructs (2)