Reference Report

Reference
Citation	Parrish, J.Z., Kim, M.D., Jan, L.Y., Jan, Y.N. (2006). Genome-wide analyses identify transcription factors required for proper morphogenesis of Drosophila sensory neuron dendrites. Genes Dev. 20(7): 820--835. (Export to RIS)
FlyBase ID	FBrf0190556
Publication Type	Research paper
PubMed ID	16547170
PubMed Abstract	Dendrite arborization patterns are critical determinants of neuronal function. To explore the basis of transcriptional regulation in dendrite pattern formation, we used RNA interference (RNAi) to screen 730 transcriptional regulators and identified 78 genes involved in patterning the stereotyped dendritic arbors of class I da neurons in Drosophila. Most of these transcriptional regulators affect dendrite morphology without altering the number of class I dendrite arborization (da) neurons and fall primarily into three groups. Group A genes control both primary dendrite extension and lateral branching, hence the overall dendritic field. Nineteen genes within group A act to increase arborization, whereas 20 other genes restrict dendritic coverage. Group B genes appear to balance dendritic outgrowth and branching. Nineteen group B genes function to promote branching rather than outgrowth, and two others have the opposite effects. Finally, 10 group C genes are critical for the routing of the dendritic arbors of individual class I da neurons. Thus, multiple genetic programs operate to calibrate dendritic coverage, to coordinate the elaboration of primary versus secondary branches, and to lay out these dendritic branches in the proper orientation.
DOI	10.1101/gad.1391006
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genes Dev.
Title	Genes & Development
Publication Year	1987-
ISBN/ISSN	0890-9369
Data from Reference
Alleles (18)
	ab^k02807 Adf1⁰¹³⁴⁹ brm^unspecified E(bx)^ry122 Elongin-C^unspecified gro^unspecified MED24^BG01670 Mi-2^j3D4 Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} N^l1N-ts1 nvy^PDFKG1 Scer\GAL4^109(2)80 Scer\GAL4²²¹ sens^E58 shot³ sna¹⁸ ttk^03A wor¹
Constructs (1)
	P{UAS-mCD8::GFP.L}
Genes (84)
	ab Acf1 Adf1 aop Arc42 asf1 ato Bap55 Bap60 bigmax bon brm Caf1 CG2678 CG4328 CG5343 CG7056 CG9104 CG17118 CG34340 chm ci d4 dpn E2f E(bx) E(spl)m7-HLH E(spl)m8-HLH E(z) EcR Elongin-C esc Ets21C fd3F gcm2 Gcn5 gro ham HmgD Iswi jumu kni l(3)mbt lbe mbf1 MED4 MED11 MED24 MEP-1 Mi-2 Mmus\Cd8a N nerfin-1 Not1 nvy Pop2 Ptx1 pygo Rpd3 RpS29 run Scer\GAL4 scrt sens seq shot Sin3A Sirt2 sna Snr1 sqz stan Su(z)12 sv Tab2 Taf4 Tango10 tgo trh ttk tum usp wor zf30C
Insertions (2)
	P{GawB}109(2)80 P{GawB}221