Reference Report

Reference
Citation	Teleman, A.A., Cohen, S.M. (2006). Drosophila lacking microRNA miR-278 are defective in energy homeostasis. Genes Dev. 20(4): 417--422. (Export to RIS)
FlyBase ID	FBrf0190566
Publication Type	Research paper
PubMed ID	16481470
PubMed Abstract	The mechanisms that control energy homeostasis and tissue growth during development are closely linked through the insulin signal transduction pathway. Changes in the level of insulin and other hormones reflect the nutritional status of the animal to control circulating sugar levels and fat metabolism. Systemic defects in insulin responsiveness can lead to elevated circulating glucose levels and fat accumulation. Here we present evidence that the microRNA miR-278 plays a role in the control of energy homeostasis in Drosophila. miR-278 mutants have elevated insulin production and are correspondingly lean. Despite the elevated insulin levels, miR-278 mutants have elevated circulating sugar, mobilized from adipose-tissue glycogen stores. We provide evidence that miR-278 mutants are insulin resistant and that miR-278 acts through regulation of the expanded transcript.
DOI
Related Publication(s)
Erratum	Erratum for "Drosophila lacking microRNA miR-278 are defective in energy homeostasis". Teleman et al., 2006, Genes Dev. 20(7): 913 [FBrf0194234]
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Secondary IDs
Language of Publication	English
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Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Genes Dev.
Title	Genes & Development
Publication Year	1987-
ISBN/ISSN	0890-9369
Data from Reference
Alleles (22)
	Avic\GFP^Scer\UAS.cUa chico^unspecified Ecol\lacZ^ex-e1 ex^e1 ex^Scer\UAS.cBa mir-278^EPg26043 mir-278^g-1a mir-278^G7A mir-278^Gal4KI mir-278^KO mir-278^Scer\UAS.cTa mir-278^tub.PT Pi3K92E^unspecified Ppyr\LUC^{tub.2xmir-278.3'UTR} Ppyr\LUC^tub.ex.3'UTR Scer\GAL4^ap-md544 Scer\GAL4^dpp.blk1 Scer\GAL4^en-e16E Scer\GAL4^GMR.PF Scer\GAL4^hs.2sev Scer\GAL4^mir-278.PT Scer\GAL4^{mir-278-Gal4KI}
Constructs (9)
	P{?lacW} P{EPg} P{ex} P{GAL4-dpp.blk1} P{GAL4-Hsp70.sev} P{GAL4-ninaE.GMR} P{mir-278-GAL4.T} P{UAS-GFP.U} P{UAS-mir-278.T}
Genes (13)
	Akh Avic\GFP chico Ecol\lacZ ex Ilp2 Ilp3 Ilp5 mir-278 Pi3K92E Ppyr\LUC Scer\GAL4 Thor
Insertions (4)
	P{?lacW}ex^e1 P{en2.4-GAL4}e16E P{EPg}mir-278^EPg26043 P{GawB}ap^md544
Natural transposons (1)
	P-element